IJ Pharmaceutical Research

Archive

56 articles

2026-12-31

vol.25,issue1

Jun

2026

Research Article

Deciphering the Anticancer Effects of Baicalein in Human Gastric Cancer Cells: Computational Chemistry, Bioinformatics, Network Pharmacology Insights, and in vitro Experimental Validation

Bai Jing,

Ren Hui,

Li Xiao^*

Jun

2026

Preparation and Evaluation of Zn<sub>2</sub>(BDC)<sub>2</sub>(DABCO)-β-CD MOF as a Dual-Drug Delivery Nanocomposite Containing Tetracycline and Indomethacin for Skin Wound Healing in BALB/c Mice

Research Article

Preparation and Evaluation of Zn₂(BDC)₂(DABCO)-β-CD MOF as a Dual-Drug Delivery Nanocomposite Containing Tetracycline and Indomethacin for Skin Wound Healing in BALB/c Mice

Farya Mirzaei,

Negar Motakef Kazemi

^*,

Naser Mohamadpour Dounighi,

Mostafa Saffari,

Sepideh Arbabi Bidgoli

Jun

2026

Hepatoprotective Effects of Ethyl Acetate Extract of <i>Lygodium microphyllum</i> Leaves

Research Article

Hepatoprotective Effects of Ethyl Acetate Extract of Lygodium microphyllum Leaves

Hadi Kuncoro

^*,

Erna Muliana,

Putri Anggreini

Angga Cipta Narsa

Zulhaerana Bahar

Vina Maulidya

,et al.

Jun

2026

Research Article

CRISPR/Cas9-Engineered HEK293T Cellular Model Harboring the Pathogenic CDKL5 c.172A>T Variant Recapitulates Core Molecular Phenotypes of CDKL5 Deficiency Disorder

Fatemeh Faghihi,

Jafar Amani

^*,

Milad Gholami

Iman Salahshourifar

Jun

2026

Research Article

Buyang Tongluo Decoction Mitigates Acute Ischemic Stroke by Suppressing NLRP3/Caspase-1/GSDMD Pathway-Induced Pyroptotic Cell Death

Hai Lin,

Yi Liu,

Yongjie Gao,

Weiyu Xu,

Qi Li,

Min Li

,et al.

Jun

2026

Research Article

Novel Ethyl 2-Aminopyrano[3,2-c]isochromene-3-carboxylate Derivatives: Synthesis, Spectral Characterization, and Cytotoxicity

Mehdi Abaszadeh

Fatemeh Haghani,

Ehsan Faghihmirzaei,

Salehe Sabouri

Jun

2026

Research Article

Efficacy of a Saffron-Based (Crocus sativus L.) Herbal Supplement on Sleep Disturbances in Pulmonary Sarcoidosis: A Randomized Single-Blind Controlled Trial

Zahra Moghimi Dehkordi

Jamshid Salamzadeh

Maria Tavakoli

Atefeh Abedini

Farzaneh Dastan

Jun

2026

Research Article

Integrative Network Pharmacology and Experimental Validation Reveal Multi-target Hepatoprotective Mechanisms of Bioactive Compounds from Xiao-Yao-San

Zi-Yi Zheng

Jing-Yi Chen

Roy You Chen Quah

Guo-Hua Ding

^*,

Jing Chen

^**

Jun

2026

Research Article

Berberine Alleviates Hepatic Steatosis by Restoring CPT1α Histone Acetylation and Modulating HDAC2/SIRT2

Chenye Shi,

Shuai Ma,

Hua Bian,

Qiong Liu,

Huandong Lin,

Xin Gao

,et al.

Jun

2026

Research Article

RNA-Seq Analysis of Morphine-Induced Gene Expression Changes in the Mouse Nucleus Accumbens

Seyed Mahmoud Pourmand

Shahrzad Nazari,

Elham Nazari

Reza Arezoomandan,

Gholamreza Hassanzadeh,

Sahar Eshrati

,et al.

May

2026

Research Article

miR-146a-Enriched Mesenchymal Stem Cell-Derived Extracellular Vesicles Prolong Corneal Allograft Survival by Modulating Local and Systemic Immune Responses

Xuting He^*

May

2026

Research Article

Dendrobium officinale Polysaccharide Promotes Infected Wound Healing Through SIRT1-Regulated HMGB1-K29 Deacetylation and NF-κB Inhibition

Yutong Wu,

Mohd Hasmizam Razali,

Wentao Wu^*

May

2026

Review Article

A New Survey about Dual-Acting PARP/COX-2 Inhibitors as Cancer Chemopreventive Agents

Mohammad Ismail Mahboubi Rabbani,

Ali Aliabadi,

Leila Bayat,

Mahdokht Jafari,

Amir Hossein Bagheri,

Sarah Shateri

,et al.

Uncorrected Proof scheduled for 15, (1)

May

2026

Research Article

In silico Identification of Natural Compounds as Potential TrkA Inhibitors for Anticancer Drug Development

Mujtaba Fadhil,

Dhurgham Al-Fahad^*,

Faizul Azam,

Asadollah Asadi

^**

Final Published

May

2026

Research Article

Tanshinone IIA Alleviates Mitochondrial Dysfunction in Lipopolysaccharide-Induced Acute Kidney Injury in Mice by Activating SIRT1/PINK1-Mediated Mitophagy

Xiaoli Guo,

Yi Gao,

Rami B. Kassab,

Fangdi Zhang^*

Final Published

May

2026

Research Article

Design, Synthesis, Molecular Docking, and Preclinical Evaluation of a New Radiolabeled PEG3-Linked FAPI Derivative for Fibroblast Activation Protein Targeting

Mahshid Kiani,

Mehdi Akhlaghi,

Safura Jokar,

Omid Bavi,

Hooman Hafezi,

Khosrou Abdi

,et al.

May

2026

Research Article

Efficacy of Nanocurcumin in Preventing Paclitaxel-Induced Peripheral Neuropathy Among Breast Cancer Patients: Findings from a Double-Blind, Randomized, Placebo-Controlled Clinical Trial

Behzad Norouzi,

Majid Ghasemi

Valiollah Mehrzad

Mohammadreza Khosravifarsani,

Marjan Mansourian

Azadeh Moghaddas^*

Final Published

May

2026

Research Article

Metformin Attenuates Angiotensin II-Induced Cardiac Inflammaging-Like Injury Through Coordinated Nrf2 Activation and NF-κB Suppression

Huarui Li,

Deming Fu,

Umar Saeed,

Zahra Zahid Piracha,

Jianjun Bao^*

Final Published

May

2026

Research Article

Elucidating the Molecular Mechanisms of Angelica sinensis Against Hepatocellular Carcinoma Through Network Pharmacology, in silico Molecular Docking, and in vitro Validation

Huajun Wu

Ping Luo

Chongming Shen

May

2026

Research Article

Andrographolide Alleviates Mycoplasma pneumoniae Pneumonia in Children by Inhibiting Alveolar Epithelial Cell Pyroptosis Through the HMGB1/TLR4/NF-κB Pathway

Lijuan Zhang,

Umar Saeed,

Rui Gao^*

Final Published

May

2026

Systematic Review

Apigenin for Depression and Anxiety: A Systematic Review of Preclinical Studies

Jin Wang,

Kun Shi^*

Final Published

May

2026

Research Article

The Impact of Marijuana (Cannabis sativa) on Viability and Expression of Cardiac Markers in Human Cardiomyocytes

Hossein Kargar Jahromi

Vida Khalafi,

Vida Mirzaei,

Faezeh Ebrahimi-Zadeh,

Pouria Azami,

Tara Abdolahy

,et al.

Final Published

May

2026

Research Article

External Knowledge Search and Innovation Performance in Iranian Biopharmaceutical Firms: The Mediating Role of Knowledge Integration Capability

Fatemeh Babaei

Nazila Yousefi

^*,

Mohammad Peikanpour

Final Published

May

2026

Research Article

The Role of Methylacrylylated Hyaluronic Acid Hydrogels in Promoting Skin Wound Healing

Chunfang Zheng,

Waifung Mai,

Liqi Zou,

Lianying Li,

Bingwei Sun^*

Final Published

May

2026

Research Article

Evaluation of Mesna Co-administration in the Management of Acute Pancreatitis: A Pilot Randomized Clinical Trial

Amir Sadeghi,

Mohammad-Yousef Fazel,

Mohammad Abbasinazari^*,

Laleh Mahmoudi,

Seyed-Mehregan Sadatsafavi,

Parvaneh Mohammadi

Final Published

May

2026

Research Article

Four Steroidal Saponins Isolated from the Aerial Parts of Allium jesdianum Exhibit Antibiofilm Effects Against Colistin-Resistant Clinical Strains, with an In Silico Study

Saeid Eslami

Behzad Zolfaghari

Masoud Sadeghi Dinani,

Arezoo Mirzaee,

Hajar Sirous,

Mustafa Ghanadian

Final Published

May

2026

Research Article

Pharmacological SIRT2 Inhibition by AGK2 Attenuates Hapten-Induced Keratinocyte Inflammation via NF-κB/NLRP3 Suppression and Nrf2 Reactivation

Xianhua Qiao

Xinglong Yu

Juanjuan Gao

Chong Lv,

Fang Cheng

Final Published

Apr

2026

Research Article

Baicalein Protects H9c2 Cardiomyoblasts Against LPS-Induced Inflammatory Injury by Modulating the NF-κB/NLRP3 Inflammasome Pathway and Mitochondrial ROS

Yi Lu,

Zahra Zahid Piracha,

Umar Saeed,

Fangjun Luo^*

Final Published

Apr

2026

Research Article

Photodynamic Therapy Combined with Gemcitabine for Prostate Cancer Using Nanoprobe for in-vivo CEST Imaging

Qibo Fu,

Qian Liu,

Xianyou Zeng,

Laoji Wang,

Jierou Yan,

Ding He

,et al.

Final Published

Apr

2026

Research Article

Folic Acid Ameliorates the Chronic Constriction Injury of Sciatic Nerve -Induced Memory Impairments in Rats

Arunachalam Muthuraman

^*,

Mohamed Meeran Sheik Davooth

Seema Mehdi

^**,

Nallupillai Paramakrishnan

Satbir Kaur

Thiagharajan Venkata Rathina Kumar

,et al.

Final Published

Apr

2026

Research Article

Antimalarial Activity of Methoxylated Flavonoid Fraction (Cirsimaritin-Dominated) from Artemisia kopetdaghensis in Plasmodium berghei-Infected Mice with in silico Analysis

Roya Amirian,

Seyed Hossein Hejazi,

Naser Ghoddosi,

Hamed Fouladseresht,

Morteza Sadeghi,

Seyed Mahmoud Mousavi

,et al.

Final Published

Apr

2026

Research Article

Promising Therapeutic Potential of miR-220-3p Mimic Against Murine Trimethyltin Hippocampal Injury

Roya Khosh Ravesh,

Vahid Khodashenas,

Mina Goudarzi,

Leila Mohammadi,

Tourandokht Baluchnejadmojarad^*,

Mehrdad Roghani

Final Published

Apr

2026

Research Article

Anti-inflammation and Anti-insulin Resistance of a Compound from Vietnamese Clerodendrum chinense Leaves

Thu Thi Xuan Nguyen,

Cuong Trinh Tat^*

Final Published

Apr

2026

Research Article

Anticancer Effects of Ziziphus jujuba in Human Breast Carcinoma: An Integrated Study of Network Pharmacology, Molecular Docking and Dynamics Simulations and in-vitro Experimental Validation

Jinxin Guo,

Jing Shen

Apr

2026

Research Article

Probiotics Ameliorate Atrial Fibrillation-Associated Biomarkers and Inflammation in Rats via Modulation of the Gut Microbiota and NLRP3 Inflammasome Pathway

Yeran Zhu,

Long Bai,

Ruibin Li,

Yichen Li,

Hongxia Hou,

Jidong Zhang

Final Published

Apr

2026

Research Article

Astragalus Polysaccharide Suppresses Inflammation and Promotes Apoptosis in Hypertrophic Scars by Suppressing OGT-Mediated Nrf2 O-GlcNAcylation

Hengfei Wang^*

Final Published

Apr

2026

Research Article

miR-146a-Enriched Extracellular Vesicles Attenuate Neuroinflammation and Promote Recovery After Ischemic Stroke

Nana Hao,

FuHua Gong^*

Final Published

Apr

2026

Research Article

Wedelolactone Inhibits Hepatitis B Virus Replication by Modulating NF-κB and Nrf2/HO-1 Signaling: An in-vitro Huh7 1.3-mer HBV Plasmid Model

Bin Wang,

Xuehui Bu,

Umar Saeed,

Zahra Zahid Piracha,

Di Xiao^*

Final Published

Apr

2026

Research Article

Gamabufotalin Suppresses Colorectal Cancer Growth via Oxidative Stress-Induced Apoptosis and DNA Synthesis Inhibition

Hui Nie,

Anfang Cui,

Zhicheng Sun,

Zhaoyang Li,

Jianhua Guo,

Shuhao Fan

,et al.

Final Published

Apr

2026

Research Article

Hepatoprotective and Antioxidant Activities of a Medicine-Food Homology Formula and Its Lactiplantibacillus plantarum-Fermented Product Against Acetaminophen-Induced Oxidative Stress in HepG2 Cells

Ching-Hui Hu,

Simon Anthony Kayombo,

Chih Min Yang

Final Published

Apr

2026

Research Article

Phytochemicals Characterization and Antidiabetic Efficacy of Muntingia calabura L. Leaves Extract: In vitro and in vivo Studies

Raden Maya Febriyanti

^*,

Mayra Fauzia,

Nurqisthi Iqlimia,

Aalbrecht Alby Irawan

Dwintha Lestari,

Yoppi Iskandar

,et al.

Final Published

Mar

2026

Research Article

Establishing 18F-PSMA-1007 Production in Armenia: Radiosynthesis and Comprehensive Quality Control

Hayk Petrosyan

^*,

Marine Mnatsakanyan

Isabella Karapetyan

Andranik Manukyan

Gurgen Elbakyan

Davit Arshakyan

,et al.

Final Published

Mar

2026

Research Article

Hydroalcoholic Extract of Ferula aucheri Shows Anti-depressant Effect Against Lipopolysaccharide-Induced Depression in Mice: Involvement of NF-κB and TLR4 Signaling Pathway

Mohammad Mehdi Gravandi

Maryam Naseri,

Nasim Jamshidi,

Samira Shirooie

Final Published

Feb

2026

Research Article

Vitamin P Significantly Inhibits the Expression of Ki67 and VEGF and Promotes the Apoptosis of Colorectal Cancer Cells

Xin Zhao,

Shang Guo,

Rongwei Shen,

Wei Zhang,

Yamin Zhang^*

Final Published

Feb

2026

Research Article

Quercetin Induces Macrophage Polarization through PI3K-AKT Pathway in Atherosclerosis: Network Pharmacology, Molecule Docking and in vitro Analysis

Li Wang,

Yifan Han,

Yuyu Lei,

Jingfeng Liu^*,

Jiajun Yu,

Guiyu Li

Final Published

Feb

2026

Research Article

Innovative Peptide Therapeutics for SARS-CoV-2: Design, Docking, and Functional Analysis

Samaneh Karimkhanilouei,

Saeid Ghorbian

^*,

Sanaz Mahmazi,

Changiz Ahmadizadeh,

Keivan Nedaei

Final Published

Feb

2026

Research Article

Affordability Analysis of Selected Medicines in Iran: A National Cross-sectional Survey Using World Health Organization Out-of-Pocket Methodology

Fatemeh Soleymani

Amirhossein Abdi

Alireza Mirzaei,

Mohammad Mahdi Raeis Zadeh

Ali Zeinalkhani,

Behzad Fatemi

Final Published

Feb

2026

Research Article

Pharmaceutical Utilization Review: A Five-Year Time Trend Analysis of the Pharmaceutical Market in Iran

Mohammadamir Nemati

Behzad Fatemi

Fatemeh Soleymani

^*,

Meysam Seyedifar

Donya Zali

Zahra Shahali

,et al.

Final Published

Feb

2026

Research Article

Acylglycerol Kinase 2-mediated Inhibition of Sirtuin 2 Restores AMPK/AKT/mTOR Signaling Balance in Podocytes: A Pharmacological Strategy for Diabetic Nephropathy

Zahra Zahid Piracha,

Umar Saeed^*,

Syed Muhammad Aun Raza,

Zia Ashraf,

Bazaid Muhammad,

Mehedi Tubaishi Rubab

,et al.

Final Published

Feb

2026

Research Article

Determining Modern Marketing Mix Elements and Their Measurement Indicators for Selling Cosmetic and Health Products in Iranian Pharmacies: A Descriptive-Analytical Cross-sectional Study

Reza Yaghoubi Nezhad,

Majid Annabi^*,

Amin Akbari,

Yasaman Bastami,

Mahdi Maleki Zadeh

Final Published

Feb

2026

Research Article

Comparison of the Effects of Sevoflurane and Isoflurane During Liver Transplant Surgery on the Short-Term Cardiac, Hepatic, and Renal Outcome: A Randomized Clinical Trial

Mohammadreza Moshari

Sadaf Tahery

Mastaneh Dahi Taleghani

Shide Dabir

Maryam Vosoughian

Soudeh Tabashi

,et al.

Final Published

Feb

2026

Research Article

Effect of Lemon Inhalation Aromatherapy on Postoperative Pain, Nausea and Vomiting, Delirium, and Inflammatory Markers After Coronary Artery Bypass Grafting: A Triple-Blind Randomized Trial

Siavash Sangi

Seyed Mohammadreza Amouzegar Zavareh^*,

Hedayat Sahraei,

Mojtaba Sepandi,

Alireza Moradi

Final Published

Feb

2026

Research Article

Comparative Study on the Effects of Ginseng and Green Tea Extracts on Selected Lipid Metabolism Markers in Adipocyte

Mandana Salehi,

Kahin Shahanipour

^*,

Ramesh Monajemi,

Parisa Mohamadynejad

Final Published

Feb

2026

Research Article

KIM-1 as an Early Diagnostic Biomarker of Cisplatin-Induced Acute Kidney Injury

Ai-Hui Jin,

Yan-Jie Zheng,

Chen-Long Xu,

Li Zhou,

Hao Wang^*,

Wen-Juan Wang^**

Final Published

Feb

2026

Research Article

Impact of Mild Traumatic Brain Injury (mTBI) on CYP2D6 Activity and the Restorative Effects of Melatonin and Vitamin C Supplementation

Kaveh Berenjian,

Ziba Gholipour,

Mohammadreza Khoshayand,

Mohammad Sharifzadeh,

Mohammadreza Rouini,

Yalda Hosseinzadeh Ardakani^*

Final Published

Feb

2026

Research Article

Dual TYK2/JAK1 Inhibition by Brepocitinib Reprograms Synoviocyte Pathobiology: Mechanistic Insights Into Targeted Therapy for Rheumatoid Arthritis

Umar Saeed^*,

Zahra Zahid Piracha,

Andromeda M. Nauli,

Surya M. Nauli^**

Final Published

Share it!

Author Services