Studying Outbreak of Pain Relieving by Three Drugs Including Alfentanil, Magnesium Sulfate and Ketamine during Intravenous Injection of Propofol

authors:

avatar Majid Nekoofard 1 , * , avatar Pooriya Abdolmaleki 2 , avatar Maryam Asli 3

Department of Anesthesiology, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran., Andorra
Students Research Committee, AJA University of Medical Sciences, Tehran, Iran, Andorra
Department of Infectious Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Andorra
Annals of Military and Health Sciences Research: Vol.13, issue 3; e58736
published online: September 14, 2015
article type: Original Article
received: July 14, 2015
accepted: August 14, 2015

how to cite: Nekoofard M, Abdolmaleki P , Asli M . Studying Outbreak of Pain Relieving by Three Drugs Including Alfentanil, Magnesium Sulfate and Ketamine during Intravenous Injection of Propofol. Ann Mil Health Sci Res. 2015;13(3):e58736. 

Abstract

Purpose: Propofol is one of the most common drugs used in anesthesia induction and the pain during its intravenous injection is one of the most important side effectsthat it has. Therefore, many methods and drugs have been examined so far to reduce or eliminate this side effect. In this study a lot the effects of Alfentanil, Magnesium Sulfate and Ketamine drugs on reducing the pain during intravenous injection of Propofol are investigated. Materials and Methods: This study was performed on 220 patients who underwent orthopedic surgeries in Poursina hospital in 2010. The intensity of Propofol intravenous injection pain is measured after using premedication by Visula Analogue Scale (VAS). The results are analyzed using Chi square and Post hoc tests. Results: According to the gathered data and analysis of variance statistic tests, we found that after Propofol injection there is a meaningful difference in quantity of VAS score among the studied groups (Chi square = 49.78 and df = 3 and P = .0001). According to Post hoc test the VAS score in Magnesium Sulfate group has a meaningful difference in comparison to other groups, while there is no meaningful difference among other groups (P = .05). Conclusion: Despite the reduction the Propofol intravenous injection pain in three studied drugs in this thesis, there is no preference among them

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