Fullerene effect on chemical properties of antihypertensive clonidine in water phase

authors:

avatar Roya Ahmadi 1 , * , avatar Mandana Pirahan-Foroush 2

Department of Chemistry, Iran
Department of Chemistry, Andorra
Annals of Military and Health Sciences Research: Vol.12, issue 1; e63660
published online: January 22, 2014
article type: Original Article
received: September 24, 2013
accepted: December 18, 2013

how to cite: Ahmadi R, Pirahan-Foroush M . Fullerene effect on chemical properties of antihypertensive clonidine in water phase. Ann Mil Health Sci Res. 2014;12(1):e63660. 

Abstract

Materials and Methods: This study was carried out using computerized calculations of Gaussian program in Becke 3-parameters Lee-Yang-Parr (B3lyp/6-31g level in water on clonidine drug  and its fullerene connected form. Impact of fullerene on an anti-blood pressure medicine known as clonidine was analyzed as changes in some properties including energetic levels, stability, highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) levels, chemical hardness, and electrophilicity    properties.

Results: Clonidine lowers blood pressure by decreasing the levels of certain chemicals in blood. This allows blood vessels to relax and the heart to beat more slowly and easily. Results indicated that combining medicine and C60 considerably decreases the energy level and increases the bipolar momentum. Therefore, solubility and reacting ability of the medicine increases in

solution phase of the  water.

Conclusion: Totally, combining fullerene structure to an anti-blood pressure medicine, like clonidine, as a nano-carrier enhances the reaction ability of the medicine and it gains more solubility properties in the human   body.

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