Can Fusion Proteins Be Considered a New Candidate for Tuberculosis Vaccine?

authors:

avatar Sepehr Navid 1 , avatar Masoud Keikha ORCID 1 , *

Department of Microbiology, School of Medicine, Isfahan Medical University, Isfahan, Iran

how to cite: Navid S, Keikha M. Can Fusion Proteins Be Considered a New Candidate for Tuberculosis Vaccine?. Gene Cell Tissue. 2018;5(3):e79943. https://doi.org/10.5812/gct.79943.

References

  • 1.

    World Health Organization (WHO). Global tuberculosis report 2015. WHO; 2015.

  • 2.

    Daniel TM. The history of tuberculosis. Respir Med. 2006;100(11):1862-70. [PubMed ID: 16949809]. https://doi.org/10.1016/j.rmed.2006.08.006.

  • 3.

    Li W, Deng G, Li M, Zeng J, Zhao L, Liu X, et al. A recombinant adenovirus expressing CFP10, ESAT6, Ag85A and Ag85B of Mycobacterium tuberculosis elicits strong antigen-specific immune responses in mice. Mol Immunol. 2014;62(1):86-95. [PubMed ID: 24980867]. https://doi.org/10.1016/j.molimm.2014.06.007.

  • 4.

    Soleimanpour S, Farsiani H, Mosavat A, Ghazvini K, Eydgahi MR, Sankian M, et al. APC targeting enhances immunogenicity of a novel multistage Fc-fusion tuberculosis vaccine in mice. Appl Microbiol Biotechnol. 2015;99(24):10467-80. [PubMed ID: 26373723]. https://doi.org/10.1007/s00253-015-6952-z.

  • 5.

    Pepponi I, Diogo GR, Stylianou E, van Dolleweerd CJ, Drake PM, Paul MJ, et al. Plant-derived recombinant immune complexes as self-adjuvanting TB immunogens for mucosal boosting of BCG. Plant Biotechnol J. 2014;12(7):840-50. [PubMed ID: 24629003]. https://doi.org/10.1111/pbi.12185.

  • 6.

    Brandt L, Oettinger T, Holm A, Andersen AB, Andersen P. Key epitopes on the ESAT-6 antigen recognized in mice during the recall of protective immunity to Mycobacterium tuberculosis. J Immunol. 1996;157(8):3527-33. [PubMed ID: 8871652].

  • 7.

    Liu X, Peng J, Hu L, Luo Y, Niu H, Bai C, et al. A multistage mycobacterium tuberculosis subunit vaccine LT70 including latency antigen Rv2626c induces long-term protection against tuberculosis. Hum Vaccin Immunother. 2016;12(7):1670-7. [PubMed ID: 26901244]. [PubMed Central ID: PMC4964814]. https://doi.org/10.1080/21645515.2016.1141159.

  • 8.

    McHeyzer-Williams M, Okitsu S, Wang N, McHeyzer-Williams L. Molecular programming of B cell memory. Nat Rev Immunol. 2011;12(1):24-34. [PubMed ID: 22158414]. [PubMed Central ID: PMC3947622]. https://doi.org/10.1038/nri3128.

  • 9.

    Qiao SW, Kobayashi K, Johansen FE, Sollid LM, Andersen JT, Milford E, et al. Dependence of antibody-mediated presentation of antigen on FcRn. Proc Natl Acad Sci U S A. 2008;105(27):9337-42. [PubMed ID: 18599440]. [PubMed Central ID: PMC2453734]. https://doi.org/10.1073/pnas.0801717105.

  • 10.

    Levin D, Golding B, Strome SE, Sauna ZE. Fc fusion as a platform technology: potential for modulating immunogenicity. Trends Biotechnol. 2015;33(1):27-34. [PubMed ID: 25488117]. https://doi.org/10.1016/j.tibtech.2014.11.001.

  • 11.

    Khademi F, Derakhshan M, Yousefi-Avarvand A, Tafaghodi M, Soleimanpour S. Multi-stage subunit vaccines against Mycobacterium tuberculosis: an alternative to the BCG vaccine or a BCG-prime boost? Expert Rev Vaccines. 2018;17(1):31-44. [PubMed ID: 29148853]. https://doi.org/10.1080/14760584.2018.1406309.

  • 12.

    Mosavat A, Soleimanpour S, Farsiani H, Sadeghian H, Ghazvini K, Sankian M, et al. Fused Mycobacterium tuberculosis multi-stage immunogens with an Fc-delivery system as a promising approach for the development of a tuberculosis vaccine. Infect Genet Evol. 2016;39:163-72. [PubMed ID: 26835592]. https://doi.org/10.1016/j.meegid.2016.01.027.

  • 13.

    Rowland R, McShane H. Tuberculosis vaccines in clinical trials. Expert Rev Vaccines. 2011;10(5):645-58. [PubMed ID: 21604985]. [PubMed Central ID: PMC3409871]. https://doi.org/10.1586/erv.11.28.

  • 14.

    Pitt JM, Blankley S, McShane H, O'Garra A. Vaccination against tuberculosis: how can we better BCG? Microb Pathog. 2013;58:2-16. [PubMed ID: 23257069]. https://doi.org/10.1016/j.micpath.2012.12.002.

  • 15.

    Langermans JA, Doherty TM, Vervenne RA, van der Laan T, Lyashchenko K, Greenwald R, et al. Protection of macaques against Mycobacterium tuberculosis infection by a subunit vaccine based on a fusion protein of antigen 85B and ESAT-6. Vaccine. 2005;23(21):2740-50. [PubMed ID: 15780721]. https://doi.org/10.1016/j.vaccine.2004.11.051.

  • 16.

    Doherty TM, Andersen P. Vaccines for tuberculosis: novel concepts and recent progress. Clin Microbiol Rev. 2005;18(4):687-702. [PubMed ID: 16223953]. [PubMed Central ID: PMC1265910]. https://doi.org/10.1128/CMR.18.4.687-702.2005.