Abstract
Background and Aims: Hepatitis B virus infection is still a major public health concern all over the world, and much research must be carried out on the various aspects of this issue. Since infection with hepatitis B virus in pregnant mothers is a threat for both mother and her fetus, this study was performed to determine the relationship between maternal HBsAg carrier status and perinatal outcome.
Methods: A retrospective case-control study was performed on 450 carriers of hepatitis B surface antigen (HBsAg) pregnant women and compared to 450 controls. Both groups were matched for age, parity, and body mass index (BMI).
Results: When compared to the control group, patients with HBsAg displayed significantly higher incidence of gestational diabetes mellitus (GDM) (7.7% vs. 2% P=0.001), increased hospitalization period after delivery (22.9% vs. 3.33%, P<0.0001), preterm labor at less than 37 weeks (10.9% vs. 2.67%, P<0.0001), pregnancy induced hypertension (13% vs. 2.89%, P<0.0001), and preterm premature rupture of membranes (3.55% vs. 1.1%, P=0.03). Also, the incidence of macrosomy (6.67% vs. 2.22%, P=0.02), intrauterine fetal death (5.56% vs. 0.44%, P=0.001), still birth (2.89% vs. 0.44%, P=0.005), and NICU admission (25.78% vs. 2.22%, P<0.0001) in the carrier mothers were higher.
Conclusions: HBsAg carriers have increased risk of hospitalization period after delivery, preterm labor, gestational hypertension, preterm premature rupture of membranes. In addition higher incidence of macrosomy, intrauterine fetal death, still birth, and NICU admission were observed. Therefore our results showed HBsAg carrier mothers have increased maternal and neonatal complications.
Keywords
Full Text
Full text is available in PDF