Serological Markers of Blood Borne Viruses among Persons with Combined Factor V and VIII Deficiency

authors:

avatar Hassan Mansouritorghabeh 1 , * , avatar Reza Farid Hosseini 2 , avatar Aliakbar Pourfathollah 3 , avatar Azizollah Behjati 2

Immunology Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, mansouritorghabe@mums.ac.ir, Khorasan-e-Razavi, IR.Iran
Immunology Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Khorasan-e-Razavi, IR.Iran
Experimental Hematology and Blood Banking Group, Medical Sciences School, Tarbiat Modarres University (TMU), Tehran, IR.Iran
Hepatitis Monthly: Vol.8, issue 3; 221-224
article type: Brief Report
received: May 4, 2008
accepted: July 13, 2008

how to cite: Mansouritorghabeh H, Hosseini R, Pourfathollah A, Behjati A. Serological Markers of Blood Borne Viruses among Persons with Combined Factor V and VIII Deficiency. Hepat Mon. 2008;8(3): 221-224. 

Abstract

Background and Aims: Combined factor V and VIII deficiency (CF5F8D) is a rare hemorrhagic disorder. Treatment of patients with blood products has been associated with infections with blood-borne viruses. Due to absence of any survey on status of blood borne viruses in individuals with CF5F8D, we tried to address this question.

Methods: Among 25 known cases, 24 individuals were assessed for hepatitis B and C viruses (HBV & HCV), human T lymphotropic virus type one (HTLV-I) and human immunodeficiency virus type1/2 (HIV1/2) using enzyme linked immunosorbent assay method.

Results: In the group under survey, 2 cases (8.3%) were positive for anti-HCV. There was no infection with HBV, HTLV-I and HIV.

Conclusions: Hepatitis C is a major health problem in CF5F8D, as in hemophiliacs, and may need more attention from manufacturers of blood products and more careful pre-transfusion screening of blood products for anti-HCV.

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