Alteration in Cellular Immunity after Chronic Hepatitis B Deteriorated into Severe Hepatitis and Its Significance

Gholam Ali Ghorbani; Seyed-Moayed Alavian; Ali Akbar Esfahani; Shervin Assari

doi:10.5812/tjms.10606

Hepatitis Monthly

Official Journal of Research Center for Gastroenterology and Liver Diseases

Home

Current Issue Accepted Manuscripts All Issues In Press Articles Search

Instructions

Journal Information Boards and committees Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Reviewer and AE Registration Form Support Contact Us

APC

Authors Guide Submit Manuscript

Alteration in Cellular Immunity after Chronic Hepatitis B Deteriorated into Severe Hepatitis and Its Significance

Author(s):

Gholam Ali Ghorbani^1,*,

Seyed-Moayed Alavian^{1, 2},

Ali Akbar Esfahani¹,

Shervin Assari³

1Military Health Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

2Baqiyatallah Research Center for Gastroenterology and Liver Diseases (BRCGL), Baqiyatallah University of Medical Sciences & Tehran Hepatitis Center, Tehran, Iran

3Medicine and Health Promotion Institute, Tehran, Iran

Hepatitis Monthly:Vol. 7, issue 3; 810-815

Published online:Oct 31, 2011

Article type:Research Article

Received:Jan 17, 2011

Accepted:Apr 23, 2011

How to Cite:Ghorbani G A, Alavian S, Esfahani A A, Assari S. Alteration in Cellular Immunity after Chronic Hepatitis B Deteriorated into Severe Hepatitis and Its Significance.Hepat Mon.2011;7(3):e70069.

Abstract

Background: It is difficult to predict what type of chronic hepatitis B (CHB) progresses to chronic severe hepatitis B.
Objectives: This study aimed to observe changes in the HBV-specific and -nonspecific cellmediated immune responses after CHB deteriorates into severe hepatic disease and explore the significance of such changes.
Patients and Methods: This study aimed to observe changes in the HBV-specific and -nonspecific cell-mediated immune responses after CHB deteriorates into severe hepatic disease and explore the significance of such changes.
Results: In 49 of 255 CHB patients (19.22%), the disease developed into chronic severe hepatitis (early stage) an average of 10.06 ± 1.73 days after admission. CD4+ and NK cells levels in Group A were lower after progression into severe hepatitis than on the second day of admission (baseline) (P < 0.01). CD8+ cells and nonspecific CTL levels in Group A were higher after progression than at baseline (P < 0.01), and latter was higher than in Group B at baseline (P < 0.01); the levels of CD8+ cells and nonspecific CTLs in Group A after progression were significantly higher than those of Group B 10 days after admission (P < 0.01). There were no significant differences in HBV-specific CTL levels in Group A before and after progression to severe hepatitis (P > 0.05).
Conclusions: Our results suggest that the immunological pathogenesis of chronic severe hepatitis B is related to significant rises in CD8+ and nonspecific CTL levels and that such increases predict that the disease will deteriorate into severe hepatitis.

Keywords

Fulltext

Full text is available in PDF

Import into EndNote Import into BibTex

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 1 month ago
Scopus by Title: 0
Last Update: 1 month ago
Scopus by Title (Ref): 0
Last Update: 1 month ago
CrossRef: 0
Last Update: 6 days ago

Metrics

Purchasing Reprints

Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here ( https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.

Search Relations

Author(s):

Gholam Ali Ghorbani:[PubMed][Scholar]
Seyed-Moayed Alavian:[PubMed][Scholar]
Ali Akbar Esfahani:[PubMed][Scholar]
Shervin Assari:[PubMed][Scholar]

Official Journal of Research Center for Gastroenterology and Liver Diseases

Outlines

Alteration in Cellular Immunity after Chronic Hepatitis B Deteriorated into Severe Hepatitis and Its Significance

Abstract

Fulltext

Last Update: 1 month ago

Last Update: 1 month ago

Last Update: 1 month ago

Last Update: 6 days ago