Association of interleukin 18 gene promoter polymorphisms with HBV recurrence after liver transplantation in Han Chinese population

authors:

avatar Liming Wu 1 , avatar Lin Chen 1 , avatar Lin Zhou 1 , avatar Haiyang Xie 1 , avatar Bajin Wei 1 , avatar Shengyong Yin 1 , avatar Yufu Ye 1 , avatar Weijia Fang 1 , avatar Shusen Zheng 2 , *

1) Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health. 2) Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine Zhejiang University, China
1) Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health. 2) Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine Zhejiang University, shusenzheng@zju.edu.cn, China
Hepatitis Monthly: Vol.11, issue 6; 469-474
article type: Research Article
received: November 23, 2010
accepted: March 4, 2011

How To Cite Wu L, Chen L, Zhou L, Xie H, Wei B, et al. Association of interleukin 18 gene promoter polymorphisms with HBV recurrence after liver transplantation in Han Chinese population. Hepat Mon. 2011;11(6): 469-474. 

Abstract

Background: There is growing evidence suggesting that interleukin-18 (IL-18) plays a crucial role in viral clearance and disease pathogenesis, and that single nucleotide polymorphisms (SNPs) within the gene may influence its production.
Objectives: To investigate the potential association of two polymorphisms ( 137G/C and 607C/A) in the promoter region of the IL-18 gene with the risk of HBV recurrence after liver transplantation (LT) in Han Chinese patients.
Patients and Methods: IL-18 promoter genotyping was performed by the snapshot technique in 125 patients with HBV-related end-stage liver disease (ESLD) receiving LT in our center from 2004 to 2008.
Results: Among the study samples, no significant association between the IL-18 promoter polymorphisms ( 137G/C and 607C/A) or haplotypes and HBV recurrence after LT was found.
Conclusions: The polymorphisms ( 137G/C and 607C/A) in the promoter region of the IL-18 gene may not play a key role in HBV recurrence after LT in Han Chinese population, and may not be suitable predictors for HBV recurrence in clinical practice.

  • Implication for health policy/practice/research/medical education:
    The research is helpful to other scientists investigating the association of cytokine SNPs with HBV recurrence after liver transplantation. Reading this article is suggested for all immunologists and GI internists.
  • Please cite this paper as:
    Wu L, Chen L, Zhou L, Xie H, Wei B, Yin S, et al. Association of interleukin 18 gene promoter polymorphisms with HBV recurrence after liver transplantation in Han Chinese population. Hepat Mon. 2011;11(6):469-74.

2011 Kowsar M.P.Co. All rights reserved.

Full Text

Full text is available in PDF