The Influence of Human Leukocyte Antigen and IL-10 Gene Polymorphisms on Hepatitis B Virus Outcome

authors:

avatar Amitis Ramezani 1 , avatar Mohammad Banifazl 1 , avatar Setareh Mamishi 1 , avatar Masoomeh Sofian 2 , avatar Ali Eslamifar 1 , avatar Arezoo Aghakhani 3 , *

1) Clinical Research Department, Pasteur Institute of Iran. 2) Pediatric Infectious Disease Research Center, Tehran University of Medical sciences, IR Iran
TPIRC (Tuberculosis and Pediatric Infectious Research Center), Arak University of Medical Sciences, IR Iran
Clinical Research Department, Pasteur Institute of Iran, araghakhani@hotmail.com, IR Iran
Hepatitis Monthly: Vol.12, issue 5; 320-325
article type: Review Article
received: January 17, 2012
accepted: April 29, 2012
DOI: https://doi.org/10.5812/hepatmon.6094

how to cite: Ramezani A, Banifazl M, Mamishi S, Sofian M, Eslamifar A, et al. The Influence of Human Leukocyte Antigen and IL-10 Gene Polymorphisms on Hepatitis B Virus Outcome. Hepat Mon. 2012;12(5): 320-325. https://doi.org/10.5812/hepatmon.6094.

Abstract

Context: The clinical outcome of hepatitis B virus (HBV) infection is variable, ranging from spontaneous recovery to an inactive carrier state, chronic hepatitis, occult HBV infection, liver cirrhosis, or hepatocellular carcinoma.
Evidence Acquisition: This variable pattern and clinical outcomes of the infection were mainly determined by virological and host genetic factors. Since the most of host genetic factors associated with HBV infection have currently focused on human leukocyte antigen (HLA) associations and interleukin (IL)-10 gene polymorphisms, this review focuses on the recent progresses in these issues to provide prognostic markers for the outcome of HBV infection.
Results: A study on serum levels of IL-10 in occult HBV infected patients reported that the higher level of IL-10 production may suppress function of the immune system against HBV in patients with occult HBV infection. IL-10 promoter polymorphism at position -592 is associated with susceptibility to occult HBV infection.
Conclusions: Findings of this study suggest that the host HLA polymorphism is an important factor in determining outcome of HBV infection but regarding IL-10 gene promoter polymorphisms, we are still have a long way to achieve a de?nite conclusion.

Implication for health policy/practice/research/medical education:
This article provides prognostic markers including HLA and IL-10 polymorphisms for determining the outcome of HBV infection.
Please cite this paper as:
Ramezani A, Banifazl M, Mamishi S, So?an M, Eslamifar A, Aghakhani A, The In?uence of Human Leukocyte Antigen and IL-10 Gene Polymorphisms on Hepatitis B Virus Outcome. Hepat Mon. 2012;12(5):320-5. DOI: 10.5812/hepatmon.6094

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