High Serum Levels of TGF-? in Iranians With Chronic HBV Infection

authors:

avatar Hossein Khorramdelazad 1 , avatar Gholamhossein Hassanshahi 1 , avatar Behzad Nasiri Ahmadabadi 2 , avatar Mohammad Kazemi Arababadi 2 , *

Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran
Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran

how to cite: Khorramdelazad H, Hassanshahi G, Nasiri Ahmadabadi B, Kazemi Arababadi M. High Serum Levels of TGF-? in Iranians With Chronic HBV Infection. Hepat Mon. 2012;12(11):7581. doi: 10.5812/hepatmon.7581.

Abstract

Background:

The transforming growth factor-? (TGF-?) is an important cytokine with anti-inflammatory properties.

Objectives:

The main purpose of this study was to compare the serum levels of TGF-? in a group of chronic HBV infected (CHB) patients as well as healthy individuals from South-East of Iran.

Patients and Methods:

Sixty patients with CHB as well as sixty healthy individuals were enrolled in the study. ELISA technique was applied to measure the serum levels of TGF-? in both groups.

Results:

Our results revealed that the serum levels of TGF-? were significantly increased in CHB patients in compare to healthy controls.

Conclusions:

According to this result, it may be concluded that high serum levels of TGF-? may be a mechanism by which immune response against HBV is suppressed.

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