Comparing the anti-type 2 collagen antibody titer in rheumatoid factor negative vs. rheumatoid factor positive sera

authors:

avatar F Karimi 1 , * , avatar N Firoozmanesh 1

Iran

how to cite: Karimi F, Firoozmanesh N. Comparing the anti-type 2 collagen antibody titer in rheumatoid factor negative vs. rheumatoid factor positive sera. J Kermanshah Univ Med Sci. 2002;6(2):e81006. 

Abstract

Introduction and Objectives: This study was done to determine   the anti-type 2 collagen (anti cII) antibody titer  in rheumatoid factor negative(RF-)  vs. rheumatoid factor positive(RF+)   sera.
 Materials and Methods: 77 RF+  and 221 RF- sera were examined for presence and titer of  anti-type 2 collagen antibody, using the tannic acid hemagglutination method. 
 Results: Anti cII antibody was found in 67.5% and 57.9% of RF+ and RF- cases, respectively.There was no significant difference  between RF- vs. RF+ sera regarding the presence of anti cII antibody . However, there was a significant difference (p<0.001)   between RF- vs. RF+ sera regarding the titer of anti cII antibody, with significantly higher antibody levels in RF+ sera.
Discussion and Conclusions: We suggest further   studying the correlation between  anti cII antibody, RF, and disease severity in rheumatoid arthritis is worthwhile.

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