Abstract
Renal transplantation triggers an early bone loss that increases the subsequent risk of
osteoporosis and fractures. Little is known about the outcome of bone status after
transplantation, specially, in-patient of southwest region of Asia. Therefore, we conducted a
cross-sectional evaluation of bone status to find out the frequency and predictors of
osteoporosis in kidney graft recipients patients in Iran.
Spinal and hipbone mineral density were assessed using a DEXA Lunar DPX-MD scanner in
61 renal graft recipients in Tehran, Iran.
In this study, 44% of patients were men (27) and 56% of them were women (34). Mean of age
of them was accordingly 44.3± 10.44 and 40/7± 13.77. Mean of transplant duration was 33.9±
33. 2 months (minimum was 3 month and maximum 172 months). Mean of dialysis time was 12±
14 months ( 0-72 months ). Osteoporosis, according to the World Health Organization
definition, was observed in 18 patients (29.5% of the total population) in any of the Total or
Neck or L2-L4 region (14.8% in Neck, 19.7% in Total, 16.4% in L2-L4 regions). Frequency of
osteoporosis was significantly higher in lowest BMI group (p = 0.007). Age, sex, transplantation
duration, dialysis time, cause of renal failure, steroid cumulative dosage, cyclosporine
cumulative dosage, had no significant relationship with bone loss in any of regions.
These data emphasize the high prevalence of osteoporosis in Iranian kidney graft recipients.
Screening and therapeutic intervention in these patients is urgently needed.
osteoporosis and fractures. Little is known about the outcome of bone status after
transplantation, specially, in-patient of southwest region of Asia. Therefore, we conducted a
cross-sectional evaluation of bone status to find out the frequency and predictors of
osteoporosis in kidney graft recipients patients in Iran.
Spinal and hipbone mineral density were assessed using a DEXA Lunar DPX-MD scanner in
61 renal graft recipients in Tehran, Iran.
In this study, 44% of patients were men (27) and 56% of them were women (34). Mean of age
of them was accordingly 44.3± 10.44 and 40/7± 13.77. Mean of transplant duration was 33.9±
33. 2 months (minimum was 3 month and maximum 172 months). Mean of dialysis time was 12±
14 months ( 0-72 months ). Osteoporosis, according to the World Health Organization
definition, was observed in 18 patients (29.5% of the total population) in any of the Total or
Neck or L2-L4 region (14.8% in Neck, 19.7% in Total, 16.4% in L2-L4 regions). Frequency of
osteoporosis was significantly higher in lowest BMI group (p = 0.007). Age, sex, transplantation
duration, dialysis time, cause of renal failure, steroid cumulative dosage, cyclosporine
cumulative dosage, had no significant relationship with bone loss in any of regions.
These data emphasize the high prevalence of osteoporosis in Iranian kidney graft recipients.
Screening and therapeutic intervention in these patients is urgently needed.
Keywords
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© 2003, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.