Kowsar Arch Pediatr Infect Dis 2322-1836 7 1 2018 10 21 10.5812/pedinfect.82540 Zahra Pourmoghaddas Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Narges Ansari Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Hezar Jerib Ave., Isfahan 81746-75731, Iran Bahar Dehghan Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Fatemeh Famori Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Hosein Saneian 1Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran, 1Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Research Article 2018 9 9 2018 7 23 2018 10 21 2019 01 31 Objectives : The aim of this study was to evaluate endothelial dysfunction in pediatric patients with Helicobacter pyloriinfection. Methods : In a cross sectional study, 50 children between six and twelve years old were evaluated for Helicobacter pyloriinfection by a histopathologic specimen. C-reactive protein (CRP) and Interleukin -12 of all subjects was checked. Endothelial dysfunction was evaluated by echocardiography of brachial artery and through measuring flow mediated dilatation (FMD). Results : Mean of FMD level was significantly higher in children with H. pyloriinfection (P value: 0.04). Interlukin-12 (IL-12) was higher in children with H. pyloriinfection (P value: 0.04). Linear regression showed a positive association of Helicobacter pyloriinfection and endothelial dysfunction (beta = 0.3, P value = 0.08). Conclusions : Children with Helicobacter pyloriinfection have more endothelial dysfunction independent of IL-12. http://pedinfect.com/en/articles/82540.html https://neoscriber.org/cdn/dl/c495e9ec-2460-11e9-ab2c-27102e9bd65f