Kowsar Iran J Radiol 2008-2711 15 3 2018 6 11 10.5812/iranjradiol.63270 Chih - Chen Chang Tang - Her Jaing Tsung - Yen Chang Chao - Jan Wang Wendy Yang Chee - Jen Chang Shih - Hsiang Chen Research Article 2018 5 16 2017 10 26 2018 6 11 2018 07 31 Background : Nowadays, volumetric data acquisition has allowed for the accurate quantification of volumetric tumor burden. However, few studies have focused on the relationship between neuroblastoma tumor volume and relevant clinical parameters. Objectives : The purpose of this study was to investigate the relationship of initial computed tomography - measured primary tumor volume (CT _PTV) with 24 - hour urine vanillylmandelic acid (VMA) level and stage in patients with neuroblastoma. Patients and Methods : This retrospective study included 24 patients. The patients’ age, gender, urine VMA levels and stage at diagnosis were collected, and the CT _PTVswere calculated. The correlation between urine VMA level and CT _PTVwas assessed. The differences in CT _PTVswith respect to age of the patients (≤ 1.5 and > 1.5 years old), gender, urine VMA levels (≤ 9.8 and > 9.8 mg/24 hours) and stage (stage 4 and non - stage 4) were analyzed. Multivariate linear regression was conducted to estimate the effect of age, gender, urine VMA level, and stage at diagnosis for CT _PTV. Finally, a comparison of demographic characteristics and stage between various CT _PTVranges (< 35 and ≥ 35 cm ³) was performed. Results : A moderate correlation was observed between urine VMA level and CT _PTVin patients with neuroblastoma (r = 0.673). The median CT _PTVswere significantly larger in patients with urine VMA > 9.8 mg (P = 0.03) and in patients who were diagnosed with stage 4 (P = 0.002). The most effective variable for CT _PTVwas urine VMA level. When the urine VMA level increases 1 mg every 24 hours, the CT _PTVwill increase 4.85 cm ³. Among the patients with a CT _PTV≥ 35 cm ³, the median age was significantly higher (P = 0.011), and median urine VMA level was significantly higher (P = 0.001) than in patients with a CT _PTV< 35 cm ³. Additionally, all patients with a CT _PTV≥ 35 cm ³had stage 4 disease at the time of diagnosis (P = 0.001). Conclusion : A moderate positive quantitative correlation was observed between 24 - hour urine VMA levels and initial CT _PTV. A CT _PTV≥ 35 cm ³may therefore be used as an indicator of advanced tumor stage in neuroblastoma. http://iranjradiol.com/en/articles/63270.html https://cdn.neoscriber.org/cdn/dl/1333cb14-aa3b-11e8-b783-5f56c6ce44b7