Shiraz University of Medical Sciences Int Cardio Res J 2251-9149 16 2 2022 Jun 15 60 55 Pardis Moradnejad Behshid Ghadrdoost Anita Sadeghpour Majid Maleki Hamidreza Pasha Monireh Kamali Shirin Manshouri Ata Firouzi Sara Lotfian Azadeh Afzalnia Zahra Shafii Nasim Naderi Neda Alijani Mahshid Hesami Shabnam Boudagh Research Article 2022 Feb 22 2021 Dec 15 2022 Jun 15 2022 06 30 : Background: Infective Endocarditis (IE) is a life-threatening disease. Regardless
of improved healthcare, the incidence of IE has increased over time. A variety of
microorganisms have been found to be associated with IE.
Objectives: This study aimed to determine the incidence of various microorganisms in
patients admitted with IE and to assess their relationships with in-hospital complications.
Methods: This prospective cross-sectional study was conducted on patients with definite
or possible IE based on the Duke criteria at a tertiary referral center between 2016 and
2021. Blood cultures were performed for all the patients to document the positive or
negative blood cultures as well as the types of microorganism. Statistical analyses were
performed using the SPSS 18 software.
Results: The study population consisted of 286 patients (181 males (63.3%) and 105 females
(36.7%)) with the mean age of 49.67 ± 17.11 years. The most common cardiac predisposing
factor was the prosthetic valve (n = 110, 38.5%) followed by a history of congenital heart
disease (n = 68, 23.8%), while the most frequent non-cardiac predisposing factors were
a history of chronic kidney disease (n = 75, 26.2%) and diabetes mellitus (n = 53, 18.5%).
The most frequent causative microorganisms were coagulase-negative Staphylococcus (n
= 37, 12.9%), Staphylococcus aureus (n = 31, 10.4%), Enterococcus (n = 29, 10.1%), and
Streptococcus viridans (n = 14, 4.9%). The most common complications were acute renal
failure (26.6%), heart failure (17.5%), and pulmonary involvement (8.4%).
Conclusions: The frequencies of microorganisms related to IE, especially culturenegative
IE, vary in different countries, precluding the practical use of a specific
guideline around the world. Further research is, therefore, required to determine the
epidemiology and microbiology of IE in different countries with a view to eventually
devising an individualized guideline appropriate to the epidemiology and microbiology
of IE in every country. https://brieflands.com/articles/ircrj-121998.html No Link Coxiella burnetii Enterococcus Staphylococcus aureus Endocarditis