Shiraz University of Medical Sciences Int Cardio Res J 2251-9149 16 4 2022 Dec 31 Mohammad Ali Sadr Ameli Azin Alizadehasl Sheida Keshavari Zohre Rahbar Mahdi Khalili Sepehr Jamalkhani Zahra Shahidzadeh Marzie Bazzi Nima Sarisarraf Masood Shekarchizadeh Kamran Roudini Rasoul Azarfarin Robab Anbiaee Maedeh Barahman Zahra Hosseini Davood Khoda-Amorzideh Amir Abdi Hooman Bakhshandeh Alireza Ghavidel Mina Mohseni Zohre Kahe Saideh Jamshidi Research Article 2022 Dec 28 2022 Jul 03 2022 Dec 31 2022 12 31 : Background: Burned-out hypertrophic cardiomyopathy (BO-HCM) is complicated
by substantial adverse events. However, few studies have focused on clinical or
echocardiographic features and their prognostic values among patients with BO-HCM.
Objective: This study evaluated the clinical manifestations and prognostic value of
echocardiography in patients with BO-HCM.
Methods: The present retrospective study evaluated 401 consecutive patients referred
to the echocardiography ward of Rajaie Cardiovascular Center for evaluation of HCM
during the period from January 2010 to February 2018. Three hundred six patients who
completed the follow-up were included: 78 (25.4%) had BO-HCM and an EF of < 50%
(group 1), and 228 (74.5%) had a normal EF in their baseline TTE (group 2). Among
the group 2 population, 183 patients had a preserved EF of > 50% (group 2B), and 45
became BO-HCM at the end of their follow-up (group 2A). Clinical data were analyzed,
including medical history, electrocardiography, and echocardiography. Generalized
estimating equation (GEE) regression was performed to assess the association between
patient characteristics and burned-out HCM.
Results: An atrial fibrillation (AF) rhythm was more common in the groups with
BO-HCM (groups 1 and 2A) (32.8 vs. 14%; P = 0.002), as were Frequent premature
ventricular contractions (PVCs) (13.98 vs. 5%; P = 0.040). Moderate or severe systolic
anterior motion (SAM) was significantly more common in group 2B (LVEF > 50%)
compared with group 1 and 2A, who had an EF of ≤ 50% (32.3% vs. 7.6%; P = 0.006).
The S-wave of the right ventricle was significantly lower in groups 1 and 2A (9.73 vs. 11.8
cm/s; P < 0.001). Systolic pulmonary artery pressure (SPAP) was significantly higher in
groups 1 and 2A (38.28 vs. 29.74 mmHg, P < 0.001). The differences in the prevalence
of asymmetrical septal hypertrophy (ASH), left ventricular outlet (LVOT) obstruction,
pericardial effusion (PE), diastolic dysfunction, and mitral regurgitation (MR) were
insignificant between all groups.
Conclusions: Among the patients suffering from HCM, the presence of AF rhythm,
frequent PVCs, significant RV dysfunction, and absence of systolic anterior motion
(SAM) of mitral valve leaflets have prognostic value and might be considered predictors
for progression to BO-HCM. https://brieflands.com/articles/ircrj-130190.html No Link 1910 9180 1183