Briefland Jundishapur J Chronic Dis Care 2322-4207 10 4 2021 11 20 10.5812/jjcdc.117656 Mozhdeh Mirmoradzehi Sibi Department of Psychology, Zahedan Branch, Islamic Azad University, Zahedan, Iran Mahmoud Shirazi Department of Psychology, University of Sistan and Baluchestan, Zahedan, Iran Farhad Kahrazei Department of Psychology, University of Sistan and Baluchestan, Zahedan, Iran Zahra Ghiasi Zahedan University of Medical Sciences, Zahedan, Iran Methods Article 2021 10 29 2021 8 6 2021 11 20 2021 10 31 Background : Depression, anxiety, and stress are the most common mental disorders almost experienced by human beings. Nowadays, due to the coronavirus outbreak, people are becoming more vulnerable to these disorders. Objectives : The present study aimed to investigate the comparison of the effect of 3 treatment methods, named neuro-linguistic programming (NLP), transcranial direct current stimulation (tDCS), and neurofeedback (NFB), on patients suffering from disorders mentioned above. Methods : The research design selected for the present investigation was a quasi-experimental method consisting of pretest and posttest given to 3 experimental groups [i.e., NFB (n = 15), tDCS (n = 15), and NLP (n = 15)] and 1 control group (n = 15). The statistical population was included patients who had been referred to mental health experts at comprehensive health service centers in Zahedan, Iran (2020). The sampling procedure was based on a simple random method with a population of 68 subjects (60 main samples and 8 alternatives). Following the completion of the Depression Anxiety Stress Scales-21 (DASS-21) questionnaire, data were collected and then analyzed step by step using SPSS version 23. Results : The results of the multivariate analysis of covariance (MANCOVA) test showed that there would be no significant decrease in the mean scores of depressions, anxiety, and stress between the pre-and posttest scores of the subjects in the treatment groups (P < 0.0001). Conclusions : NLP, tDCS, and NFB were significantly effective in the treatment of depression, anxiety, and stress. Considering the importance of the findings, non-pharmacological methods could be effective in the treatment of depression, anxiety, and stress. https://sites.kowsarpub.com/jjcdc/articles/117656.html https://jjcdc.kowsarpub.com/cdn/dl/2c7dc8c0-49ef-11ec-bf98-4b7c7ae7017c Neurofeedback Transcranial Direct Current Stimulation Neuro-Linguistic Programming Depression, Anxiety Stress, Quantitative Electroencephalography