Briefland Jundishapur J Nat Pharm Prod 2228-7876 16 4 2021 9 12 10.5812/jjnpp.114152 Mahdi Jufri Faculty of Pharmacy, Universitas Indonesia, Indonesia Afifah Vardhani Faculty of Pharmacy, Universitas Indonesia, Indonesia Erni Purwaningsih Department of Pharmacy, Faculty of Medicine, Universitas Indonesia, Indonesia Research Article 2021 6 22 2021 5 3 2021 9 12 2021 11 30 Background : Ultraviolet exposure is an extrinsic factor to initiate melanogenesis, the process of melanin formation in the skin. Nowadays, natural ingredients tend to be more prevalent in cosmetic formulations due to consumers’ concern about synthetic ingredients and the risks they may represent for human health. Rice bran, the outer layer of a rice grain, can be utilized as a skin-lightening agent. Objectives : This study aimed to determine the efficacy of a lotion containing black rice bran ( Oryza sativaL. indica) ethanolic extract as a skin lightening agent. Methods : The black rice bran ethanolic extract was formulated into oil in water (o/w) lotion. In this study, 34 women applied the lotion at one side of the forearm and base placebo lotion as control at the other side of forearm. The results were tested with a paired t-test by GraphPad Prism 8.3.0 software. Results : There was a significant decrease in the melanin index and erythema index in the forearm with a lotion containing black rice bran extract (P-value < 0.0001). Conclusions : The lotion containing 10% black rice bran extract was effective as a skin lightener because it effectively reduced skin melanin production when applied topically. https://sites.kowsarpub.com/jjnpp/articles/114152.html https://jjnpp.kowsarpub.com/cdn/dl/c36cbd96-5146-11ec-a04f-c75b19672084 Black Rice Bran Skin Lightening Agent Natural Product Clinical Trials <i>Oryza sativa</i> L. <i>indica</i>