Kowsar Jundishapur J Nat Pharm Prod 2228-7876 14 1 2018 12 9 10.5812/jjnpp.57620 Oluwaseun Ruth Alara Faculty of Chemical Engineering & Natural Resources, Universiti Malaysia Pahang, Lebuhraya Tun Razak, 26300, Gambang, Pahang, Malaysia, Faculty of Chemical Engineering & Natural Resources, Universiti Malaysia Pahang, Lebuhraya Tun Razak, 26300, Gambang, Pahang, Malaysia. Tel: +601116543727 Nour Hamid Abdurahman Faculty of Chemical Engineering & Natural Resources, Universiti Malaysia Pahang, Lebuhraya Tun Razak, 26300, Gambang, Pahang, Malaysia Siti Kholijah Abdul Mudalip Faculty of Chemical Engineering & Natural Resources, Universiti Malaysia Pahang, Lebuhraya Tun Razak, 26300, Gambang, Pahang, Malaysia Olusegun Abayomi Olalere Faculty of Chemical Engineering & Natural Resources, Universiti Malaysia Pahang, Lebuhraya Tun Razak, 26300, Gambang, Pahang, Malaysia Research Article 2018 2 17 2017 7 5 2018 12 9 2019 02 28 : Vernonia amygdalinaleaf has a significant importance in food and traditional medicine. It has been reported to possess various pharmacological effects. This study was carried out to investigate the influence of microwave-assisted extraction factors on the extraction from V. amygdalinaleaves. The results highlighted that an increase in temperature deteriorated the yields of V. amygdalinaleaf. Thus, shade-dried samples gave the highest yields at the irradiation times of 10 and 2 min, microwave power of 500 and 600 W, the temperature of 100 and 80°C, the feed-to-solvent ratio of 1:10, and ethanol concentration of 60% v/v using water and ethanol as the extracting solvents, respectively. Likewise, the antioxidant assay resulted in IC ₅₀values of 260 ± 1.1 µg/mL DPPH and 149.78 ± 0.81 µg/mL ABTS for water and 204 ± 0.92 µg/mL DPPH and 31.17 ± 1.4 µg/mL ABTS for ethanol. Therefore, the synergistic mechanism of mass and heat transfer may be accounted for the accelerated extraction due to microwave energy. http://jjnpp.com/en/articles/57620.html https://neoscriber.org/cdn/dl/e575fbee-12bc-11e9-b77c-836d50e09259