Kowsar Jundishapur J Nat Pharm Prod 2228-7876 13 3 2018 8 28 10.5812/jjnpp.83494 Stepan Sergeevich Dzhimak Experimental Clinic - Laboratory of Biologically Active Substances of Animal Origin, V.M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences, Moscow, Russia, Kuban State University, 350040, St., Stavropolskaya 149, Krasnodar, Russia Alla Ivanovna Shikhliarova Experimental Clinic - Laboratory of Biologically Active Substances of Animal Origin, V.M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences, Moscow, Russia, Kuban State University, 350040, St., Stavropolskaya 149, Krasnodar, Russia Galina Vitalievna Zhukova Experimental Clinic - Laboratory of Biologically Active Substances of Animal Origin, V.M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences, Moscow, Russia, Kuban State University, 350040, St., Stavropolskaya 149, Krasnodar, Russia Alexandr Alexandrovich Basov Experimental Clinic - Laboratory of Biologically Active Substances of Animal Origin, V.M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences, Moscow, Russia, Kuban State University, 350040, St., Stavropolskaya 149, Krasnodar, Russia Oleg Ivanovich Kit Experimental Clinic - Laboratory of Biologically Active Substances of Animal Origin, V.M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences, Moscow, Russia, Kuban State University, 350040, St., Stavropolskaya 149, Krasnodar, Russia Liliya Viacheslavovna Fedulova Experimental Clinic - Laboratory of Biologically Active Substances of Animal Origin, V.M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences, Moscow, Russia, Kuban State University, 350040, St., Stavropolskaya 149, Krasnodar, Russia Tatiana Anatolievna Kurkina Experimental Clinic - Laboratory of Biologically Active Substances of Animal Origin, V.M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences, Moscow, Russia, Kuban State University, 350040, St., Stavropolskaya 149, Krasnodar, Russia Elena Alekseevna Shirnina Experimental Clinic - Laboratory of Biologically Active Substances of Animal Origin, V.M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences, Moscow, Russia, Kuban State University, 350040, St., Stavropolskaya 149, Krasnodar, Russia Tatiana Panteleevna Protasova Experimental Clinic - Laboratory of Biologically Active Substances of Animal Origin, V.M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences, Moscow, Russia, Kuban State University, 350040, St., Stavropolskaya 149, Krasnodar, Russia Mikhail Gennadievich Baryshev Experimental Clinic - Laboratory of Biologically Active Substances of Animal Origin, V.M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences, Moscow, Russia, Kuban State University, 350040, St., Stavropolskaya 149, Krasnodar, Russia Alexandr Alekseevich Timakov Experimental Clinic - Laboratory of Biologically Active Substances of Animal Origin, V.M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences, Moscow, Russia, Kuban State University, 350040, St., Stavropolskaya 149, Krasnodar, Russia Research Article 2018 4 22 2017 2 9 2018 8 28 2018 08 31 : Consumption of deuterium depleted water (DDW) (46 ± 2 ppm) as drinking water by white outbred female rats (20 - 22 months) during five weeks led to the development of a well-pronounced geroprotector effect, which manifested in occurrence of the estrous cycle restoration signs, as well as in the coat state improvement, compared with the same characteristics of animals that received drinking water with a deuterium content of 150 ppm. Besides, rats receiving DDW showed the improvement of the skin bactericidal power. Thus, experiments in mammals provided a direct confirmation of the geroprotector properties of DDW. The current study revealed a deuterium content reduction in blood (according to the NMR (nuclear magnetic resonance) spectroscopy data) and visceral organs: liver, kidney, and heart (according to the mass spectroscopy data) in animals receiving DDW. A more pronounced decrease in the deuterium content was recorded in the rat blood plasma (33.2%) compared with the deuterium content changes in visceral organs (liver -7.2%, kidney -9.7%, heart -7.3%), which generally led to a change in the direction of the D/H isotopic gradient with consumption of DDW by the animals (C _{D blood plasma}< C _{D visceral organs}). http://jjnpp.com/en/articles/83494.html https://cdn.neoscriber.org/cdn/dl/762e98ce-b4e6-11e8-8103-bf92f748dde0