1 Recurrent Extensive Bilateral Central Giant Cell Granuloma of the Maxilla: A Case Report https://brieflands.com/journals/jkums/articles/171970 10.5812/jkums-171970 1 Introduction :Central giant cell granuloma (CGCG) is a benign intraosseous lesion that occasionally exhibits invasive behavior and has an unknown etiology. It is most commonly observed in the mandible and in young patients. Extensive bilateral maxillary involvement is very rare. Case Presentation :A 40-year-old woman presented with progressive, painless swelling of the left maxilla. Physical examination revealed facial asymmetry and nasal obstruction. The lesion was nontender, with no discharge or skin discoloration, and no lymphadenopathy was detected. Laboratory tests, including phosphorus, calcium, parathyroid hormone, and alkaline phosphatase levels, were normal. Approximately five years earlier, the patient had initially presented with pain in the same region, which was considered odontogenic in origin and was managed with dental treatment and antibiotics. Three years earlier, an incisional biopsy confirmed CGCG; however, no definitive excisional treatment was performed, and regular follow-up was not maintained. The lesion subsequently progressed, leading to the current presentation with marked swelling. Early postoperative follow-up after the current treatment showed satisfactory healing, reduced swelling, improved nasal obstruction, and no treatment-related adverse effects. Cone-beam computed tomography (CBCT) showed a large lesion with wispy septa, scattered calcifications, root resorption, and extension to the pterygoid plates, nasal floor, and palate. Differential diagnoses included ameloblastoma and malignant lesions. Conclusions :Aggressive CGCG of the maxilla with extensive expansion can clinically and radiographically mimic malignant lesions. Comprehensive multidisciplinary evaluation is essential for accurate diagnosis and successful treatment. 1 8 Azita Ehsani Department of Oral and Maxillofacial Radiology, School of Dentistry, Alborz University of Medical Sciences, Tehran, Iran Iran a.ehsani92@gmail.com Atabak Mottaghi Department of Oral and Maxillofacial Surgery, School of Dentistry, Guilan University of Medical Sciences, Rasht, Iran Iran tbk_grandfathet@yahoo.com Neda Mirmohammadsadeghi Department of Oral and Maxillofacial Pathology, School of Dentistry, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran Iran nedamirmohammad78@gmail.com Marzieh Ehsani Department of Oral and Maxillofacial Radiology, School of Dentistry, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran Iran mr.ehsani2014@gmail.com No Keyword 1.pdf [0]Shrestha S, Zhang J, Yan J, Zeng X, Peng X, He B.Radiological features of central giant cell granuloma: comparative study of 7 cases and literature review. 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