Kowsar J Skin Stem Cell 2423-7086 5 3 2018 10 31 10.5812/jssc.84047 Najmosadat Atefi Iran University of Medical Sciences, Tehran, Iran Mohammad Nabavi Iran University of Medical Sciences, Tehran, Iran Shooka Esmaeeli Iran University of Medical Sciences, Tehran, Iran Zahra Azizian Iran University of Medical Sciences, Tehran, Iran, Iran University of Medical Sciences, Tehran, Iran. tel: +98-9122788611, E-mail: azizian_z@yahoo.com Hadi Mohagheghian Iran University of Medical Sciences, Tehran, Iran Shima Javadinia Tehran University of Medical Sciences, Tehran, Iran Research Article 2018 10 24 2018 9 8 2018 10 31 2018 09 30 Background : Treatment of some fungi species would result in the improvement of atopic eczema. Objectives : In this study, the anti- MalasseziaIgE in patients with atopic eczema before and after treatment with a ketoconazole shampoo was determined. Methods : In this before-after investigation, 20 consecutive patients with atopic dermatitis referring to a teaching hospital in Tehran, Iran, in 2015 were enrolled. A ketoconazole shampoo was administered two times a week each time for 5 - 10 minutes. The treatment was used for two months and monthly evaluations were done. The total IgE level and anti- MalasseziaIgE were compared at the beginning and the end of the study. Results : The results demonstrated that there was a statistically significant difference in the total Ig-E level and anti- MalasseziaIgE before and after treatment with ketoconazole. Conclusions : According to the obtained results in this study, it may be concluded that ketoconazole would result in decreased anti- MalasseziaIgE and total IgE level in patients with atopic eczema. http://journalssc.com/en/articles/84047.html https://neoscriber.org/cdn/dl/628dd85c-068a-11e9-9aa9-afa4f761c1e1