Kowsar Nephro-Urol Mon 2251-7014 10 6 2018 11 5 10.5812/numonthly.84296 Farzanehsadat Minoo Nephrology Research Center, Tehran University of Medical Science, Tehran, Iran. Center of Excellence in Nephrology, Tehran University of Medical Science, Tehran, Iran. Elham Ramezanzade Organ Transplantation Research Center, School of Medicine, Guilan University of Medical Science, Rasht, Iran., OrganTransplantation Research Center, Razi Hospital, School of Medicine, Guilan University of Medical Science. Postal Address: Razi Hospital, Rasht, Iran. Fax:+98-21-66581568. Email address: rz.elham58@gmail.com Mehrzad Mojarad Nephrology Research Center, Tehran University of Medical Science, Tehran, Iran. Azam Alamdari Nephrology Research Center, Tehran University of Medical Science, Tehran, Iran. Center of Excellence in Nephrology, Tehran University of Medical Science, Tehran, Iran. Mohammad Taghi Najafi Nephrology Research Center, Tehran University of Medical Science, Tehran, Iran. Center of Excellence in Nephrology, Tehran University of Medical Science, Tehran, Iran. Research Article 2018 10 7 2018 9 15 2018 11 5 2018 11 30 Background : Fibroblast growth factor-23 (FGF23) is a phosphaturic factor that is released from bone. A variety of bone diseases can occur in renal diseases. Objectives : This study aimed to investigate the association of FGF23 with mineral factors, PTH, and 25-hydroxyvitamin D among hemodialysis patients. Methods : This cross-sectional multicenter study was performed on 135 patients aged 18 years or over with end-stage renal disease treated with hemodialysis maintenance. FGF-23, phosphorus, Ca, Mg, PTH, 25-hydroxyvitamin D, Uric Acid, Na, and K were measured in each patient’s fasting blood sample. We used univariate and multivariate linear regressions. Results : The mean age of patients was 56.45 ± 13.64 years. The mean and median FGF23 concentration in patients were 855.07 ± 43.33 and 762.6 (IQR = 456.6 - 1430.3) pg/mL, respectively. Different variables did not show any significant difference between the two sexes. After adjustment for age, sex, dialysis time, uric acid, Na, K, and kt/V, FGF23 had a linear association with 25-hydroxyvitamin D and every 10-unit (pg/mL) increase in FGF23 was significantly associated with a 0.03 mg/mL increase in 25-hydroxyvitamin D (P = 0.04). In addition, other variables showed no significant association with FGF23. Conclusions : According to the results, FGF23 had a linear association with vitamin D and an increase in FGF23 was significantly associated with an increase in vitamin D. In addition, there was no significant association between mineral factors and PTH, and FGF23. http://numonthly.com/en/articles/84296.html https://neoscriber.org/cdn/dl/fa7c5466-f57f-11e8-80c6-7fe8cd9cc652