Evaluation of gender-related differences in response to oxidative stress in toxoplasma gondii positive serum

authors:

avatar Mahvash Jafari 1 , avatar Maryam Salehi 2 , avatar Shahnaz Shirbazou 3 , * , avatar Laila Abasian 3 , avatar Fatemeh Talebi-Meymand 3

Department of Biochemistry, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran, Andorra
Neuroscience Research Centre, Baqiyatallah University of Medical Sciences, Tehran, Iran., Andorra
Department of Parasitology, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran, Andorra
Annals of Military and Health Sciences Research: Vol.12, issue 2; e63369
published online: May 22, 2014
article type: Original Article
received: February 11, 2014
accepted: April 22, 2014

how to cite: Jafari M , Salehi M , Shirbazou S , Abasian L , Talebi-Meymand F . Evaluation of gender-related differences in response to oxidative stress in toxoplasma gondii positive serum. Ann Mil Health Sci Res. 2014;12(2):e63369. 

Abstract

Materials and Methods: This case-control study was carried out on 150 individuals who had referred to our center in Tehran. Serum was obtained from venous blood samples. Immunoglobulin G (IgG) anti-toxoplasma antibody enzyme linked immunosorbent assay (ELISA) test was performed on all of the samples. Those who were IgG positive were regarded as the case group (52 women and 23 men) and the others as the control group (43 women and 32 men). The data were analyzed by INSTAT software using ANOVA followed by    Tukey.

Results: Serum superoxide dismutase activity in men of the case group was significantly higher than in the control group (7.81 ± 0.38 vs. 6.69 ± 0.17, P = .045). Catalase activity in men of       the  case group was  significantly higher than the  control group (8.64 ±  0.55 vs.  6.23 ±  0.38,  P = .006). Glutathione S-transferase activity and malondialdehyde level in women of the case group were significantly higher than the control group (5.98 ± 0.24 vs. 4.73 ± 0.28, P = .037     and 2.3 ± 0.09 vs. 1.9 ± 0.09, P = .032, respectively). Catalase activity and glutathione level        in  women of  the  case group were lower than the  control group (6.0 ±  0.45 vs.  7.63 ±  0.48, P = .043 and 0.62 ± 0.05 vs. 0.89 ± 0.05, P = .007, respectively).

Conclusion: T. gondii infection induces oxidative stress in women’s serum because of the decreased catalase activity, glutathione depletion and increasing lipid peroxidation. The increased antioxidant enzyme activities in infected men were because of the adaptive response to the generated free radicals. Women were found to be more sensitive to the effects of toxoplasma infection on oxidative stress induction compared to    men.

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