The Relationship Between Atherosclerosis and the Intima Media Thickness of Carotid Arteries With Serum C-Reactive Protein Levels in Patients With Systemic Lupus Erythematosus

Zahra Zakeri; Sharareh Saneie Sistani; Zohre Bari; Alireza Ansari-Moghaddam; Mahmoud Imani; Mohammad Reza Miradi; Mahnaz Sandooghi

doi:10.5812/jhs.6820

Health Scope

Official Publication of Health Promotion Research Center

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https://doi.org/10.5812/jhs.6820

The Relationship Between Atherosclerosis and the Intima Media Thickness of Carotid Arteries With Serum C-Reactive Protein Levels in Patients With Systemic Lupus Erythematosus

Author(s):

Zahra Zakeri¹,

Sharareh Saneie Sistani²,

Zohre Bari³,

Alireza Ansari-Moghaddam³,

Mahmoud Imani⁴,

Mohammad Reza Miradi¹,

Mahnaz Sandooghi^1,*

1Department of Internal Medicine, Ali-Ebne-Abitaleb Hospital, Zahedan University of Medical Sciences,, Zahedan, IR Iran

2Department of Radiology, Ali-Ebne-Abitaleb Hospital, Zahedan University of Medical Sciences, , Zahedan, IR Iran

3Health Promotion Research Center, Zahedan University of Medical Sciences,, Zahedan, IR Iran

4Department of Pediatric, Ali-Ebne-Abitaleb Hospital, Zahedan University of Medical Sciences, , Zahedan, IR Iran

Health Scope:Vol. 1, issue 2; e93532

Published online:Aug 07, 2012

Article type:Research Article

Received:May 13, 2019

Accepted:Jun 26, 2012

How to Cite:Zakeri Z, Saneie Sistani S, Bari Z, Ansari-Moghaddam A, Imani M, et al. The Relationship Between Atherosclerosis and the Intima Media Thickness of Carotid Arteries With Serum C-Reactive Protein Levels in Patients With Systemic Lupus Erythematosus. Health Scope. 2012;1(2):e93532. doi: https://doi.org/10.5812/jhs.6820

Abstract

Background: Patients with systemic lupus erythematous (SLE) are more prone to atherosclerosis and cardiovascular diseases due to atherosclerosis and consequently death.

Objectives: The aim of this study was to explore a possible relationship between the intima media thickness (IMT) of carotid arteries and the levels of C-reactive protein (CRP) in SLE patients.

Patients and Methods:: Sixty SLE patients and 60 healthy persons, being matched in age, ethnicity, gender and body mass index, were recruited for the study. The thickness of intima-media of the carotid arteries and the levels of CRP were measured using color Doppler ultrasonography and highly sensitive CRP measurement methods, respectively then findings were compared between the two groups.

Results:: Ultrasonographic evaluation showed atherosclerosis in 6 (10%) and 3 persons (5%) of the patients and control groups, respectively (P = 0. 298). The mean thickness of intima-media was not significantly different between the two groups (P = 0.31).But the mean level of CRP was significantly higher in patients group (P = 0. 005).

Conclusions:: We could not find any relationship between the serum CRP level and the risk of atherosclerosis progression in patients with SLE. Perhaps, SLE alone is not an independentrisk factor for atherosclerosis.

Keywords

Systemic Lupus Erythematosus

Carotid Intima-Media Thickness

Atherosclerosis

C - Reactive Protein

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Author(s):

Zahra Zakeri:[PubMed][Scholar]
Sharareh Saneie Sistani:[PubMed][Scholar]
Zohre Bari:[PubMed][Scholar]
Alireza Ansari-Moghaddam:[PubMed][Scholar]
Mahmoud Imani:[PubMed][Scholar]
Mohammad Reza Miradi:[PubMed][Scholar]
Mahnaz Sandooghi:[PubMed][Scholar]

Official Publication of Health Promotion Research Center

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The Relationship Between Atherosclerosis and the Intima Media Thickness of Carotid Arteries With Serum C-Reactive Protein Levels in Patients With Systemic Lupus Erythematosus

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