Drug-related Atrioventricular Block: Is It a Benign Condition?

Sima Sayah; Mohammad Ali Akbarzadeh; Zahra Emkanjoo; Reza Mollazadeh; Shahab Shahrzad; Negar Bahrololoumi Bafruee

doi:10.20286/ijcp-010105

International Journal of Cardiovascular Practice

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https://doi.org/10.20286/ijcp-010105

Drug-related Atrioventricular Block: Is It a Benign Condition?

Author(s):

Sima Sayah¹,

Mohammad Ali Akbarzadeh^{2, 3,*},

Zahra Emkanjoo⁴,

Reza Mollazadeh⁵,

Shahab Shahrzad

⁴,

Negar Bahrololoumi Bafruee⁶

1Cardiology Department, Ghazvin University of Medical Sciences, Ghazvin, Iran

2Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3Department of Cardiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4Department of Pacemaker and Electrophysiology, Shaheed Rajaei Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

5Emamkhomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

6Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran

International Journal of Cardiovascular Practice:Vol. 1, issue 1; 6-9

Published online:Apr 01, 2016

Article type:Research Article

Received:Jul 22, 2015

Accepted:Aug 02, 2015

How to Cite:Sima SayahMohammad Ali AkbarzadehZahra EmkanjooReza MollazadehShahab ShahrzadNegar Bahrololoumi Bafrueeet al.Drug-related Atrioventricular Block: Is It a Benign Condition?.Int J Cardiovasc Pract.2016;1(1):e130015.https://doi.org/10.20286/ijcp-010105.

Abstract

Introduction: Prognosis of the patients with beta blocker or calcium channel blocker induced AV block is not well known to date.

Methods: All patients with symptomatic second-degree or third-degree atrioventricular block (AV) referred to our institution during one year were recuited prospectively and classified in two groups based on drug consumption (beta blocker/calcium channel blocker versus none). They were followed for six months and then collected data was analyzed.

Results: The study included 49 patients, 28 patients (age 60.1 ± 20, 19 male) did not use any beta blocker or calcium channel blocker (No- DU group) and other 21 patients (age 73.5 ± 10.4, 7 male) receivd beta blocker, calcium channel blocker or both at the time of AV block (DU group). No-DU group was significantly younger than DU group. The most common atrial rhythm in both groups was sinus. There was no significant difference in QRS wideness or ventricular rate. AV block regressed in 43% of the DU group after discontinuation of drug for fi half-life, but, Mobitz type 2 or complete AV block occurred again during six months in 50% of them without consumption of the culprit drug.

Conclusions: More than two third of the patients who developed AV block on beta blocker and/or calcium channel blocker needed permanent pacemaker in six months of follow- up, so we concluded that the development of AV block was not as benign as it seems in these patients

Keywords

Calcium Channel Blockers

Prognosis

Atrioventricular Block

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Author(s):

Sima Sayah:[PubMed][Scholar]
Mohammad Ali Akbarzadeh:[PubMed][Scholar]
Zahra Emkanjoo:[PubMed][Scholar]
Reza Mollazadeh:[PubMed][Scholar]
Shahab Shahrzad:[PubMed][Scholar]
Negar Bahrololoumi Bafruee:[PubMed][Scholar]