GnRH Analogues in the Prevention of Ovarian Hyperstimulation Syndrome

Pilar Alama; Jose Bellver; Carmen Vidal; Juan Giles

doi:10.5812/ijem.5034

International Journal of Endocrinology and Metabolism

Research Institute for Endocrine Sciences

e-ISSN 1726-9148

p-ISSN 1726-913X

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Abstract
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https://doi.org/10.5812/ijem.5034

GnRH Analogues in the Prevention of Ovarian Hyperstimulation Syndrome

Authors

Pilar Alama¹, Jose Bellver², Carmen Vidal¹, Juan Giles^1,*

1Department of Reproduction, IVI-Valencia, Plaza de la Policia Local, Valencia, Spain

2Department of Paediatrics, Obstetrics and Gynaecology, Faculty of Medicine. University of Valencia, Valencia, Spain

*Corresponding Author: Department of Reproduction, Valencia Infertility Institute, Plaza de la Policia Local 3, Valencia 46015, Spain. Tel: +34-963050900, [email protected]. Email: [email protected]

International Journal of Endocrinology and Metabolism:Vol. 11, issue 2; 107-16

Published online:Mar 31, 2013

Article type:Review Article

Received:Jul 08, 2012

Accepted:Aug 17, 2012

How to Cite:Alama P, Bellver J, Vidal C, Giles J. GnRH Analogues in the Prevention of Ovarian Hyperstimulation Syndrome. Int J Endocrinol Metab. 2013;11(2):. doi: https://doi.org/10.5812/ijem.5034

Abstract

Abstract:

The GnRH analogue (agonist and antagonist GnRH) changed ovarian stimulation. On the one hand, it improved chances of pregnancy to obtain more oocytes and better embryos. This leads to an ovarian hyper-response, which can be complicated by the ovarian hyperstimulation syndrome (OHSS). On the other hand, the GnRH analogue can prevent the incidence of OHSS: GnRH antagonist protocols, GnRH agonist for triggering final oocyte maturation, either together or separately, coasting, and the GnRH analogue may prove useful for avoiding OHSS in high-risk patients. We review these topics in this article.

KeywordsOvarian Stimulation Ovarian Hyperstimulation Syndrome Prevention GnRH Agonist GnRH Antagonist

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© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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