Diallyl Disulfide and Helicobacter pylori


avatar Sayed Alireza Mirsane 1 , * , avatar Nasrin Oraei 2

Kashan University of Medical Sciences, Kashan, IR Iran
Lecturer of Education Office, Isfahan, IR Iran

how to cite: Mirsane S A, Oraei N. Diallyl Disulfide and Helicobacter pylori. Int J Infect. 2017;4(3):e40939. doi: 10.5812/iji.40939.

Dear Editor,

Helicobacter pylori (H. pylori) is a Gram-negative bacteria that colonize in the stomach of about half of the world population is one of the most common bacterial infections worldwide. Helicobacter pylori can activate the immune response of the host. Despite a vigorous humeral and cellular immune response, if untreated, this infection becomes chronic and persists all over life (1-3). Helicobacter pylori gastric infection is a major risk factor of gastric cardiac cancer and migraine exacerbation. Unfortunately, after long-term infection, H. pylori may develop gastric cancer in some patients (4-7). According to a hadith by Muhammad the prophet (may peace be upon him), garlic is a remedial foodstuff with biological properties. On the other hand, diallyl disulfide (DADS or 4, 5-dithia-1, 7-octadiene) is the main organosulfur derivative of garlic (8). And also, DADS is found in foods such as chive oil (9), Chinese leek oil (10), garlic oil (10) and Dracocephalum kotschyi (11, 12). Researchers demonstrated that DADS is a useful and effective material to improve and treat H. pylori infection (11, 13). A study by O'Gara et al. had similar results; they concluded that antimicrobial activities of the diallyl sulfides increased with the number of sulfur atoms. They also suggested that DADS acts against the gastric ulcer caused by H. pylori (14). Corzo-Martínez showed that DADS also acts against the gastric ulcer caused by H. pylori (15). Researches indicated that H. pylori infection can motivate cells to synthesize and secrete 5-hydroxytryptamine (HT); and following that stimulate the cell to secrete 5-HT and create central nervous system (CNS) disorder by the brain-gut axis, which can increase the period and intensity of migraine headaches. Relieving H. pylori infection has beneficial results for migraine betterment because these interventions can reduce the period and intensity of this disorder (7, 16). Therefore, DADS can be a vulnerary and remedial factor for H. pylori infection and migraine. Based on the present study, it can be concluded that DADS has helpful and good efficiency in the treatment and control of H. pylori infection. Thus it can be as an anti-migraine, anti-gastric cardiac cancer and anti-gastric cancer; it can also be stated that DADS is a therapeutic substance for the other complications result from H. pylori infection. Finally, it is recommended to conduct more studies to find the new benefits of DADS.


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