Diagnostic Value of Provocative Test by Insulin Combined with Clonidine for Growth Hormone Deficiency in Children

authors:

avatar Cheng Guo 1 , avatar Li Chen 2 , *

Iranian Journal of Pediatrics: Vol.23, issue 3; 315-320
published online: May 05, 2013
article type: Research Article
received: March 14, 2012
accepted: April 06, 2013

how to cite: Guo C, Chen L. Diagnostic Value of Provocative Test by Insulin Combined with Clonidine for Growth Hormone Deficiency in Children. Iran J Pediatr. 2013;23(3): 315-320. 

Abstract

Objective: To evaluate the diagnostic value of provocative test by insulin combined with clonidine for growth hormone deficiency (GHD) during childhood
Methods: Eighty children underwent a provocative test with insulin(0.075U/Kg, intravenous) combined with clonidine (4μg/kg, orally). Among them, 40 children underwent clonidine provocative test, 40 children underwent insulin tolerance test (ITT) in another day.
Findings: The specificity of ITT+clonidine test (74%, 88%) was remarkably higher than that of ITT (48%) or clonidine test (65%). ITT+clonidine test had a better accuracy (75%, 85%) than that of ITT (63%) or clonidine test (73%)
Conclusion: We conclude that the combined clonidine+insulin test is a feasible, reliable, convenient, time saving, and safe tool for evaluation of the growth hormone (GH) axes than the clonidine test or ITT.
 

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