New Predictors for Advanced Retinopathy of Prematurity among Neonates in Tehran/Iran

Seyed-Mohammad Fereshtehnejad; Parisa Mohagheghi; Karim Poorsattar Bejeh Mir; Arash Poorsattar Bejeh Mir

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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New Predictors for Advanced Retinopathy of Prematurity among Neonates in Tehran/Iran

Author(s):

Seyed-Mohammad Fereshtehnejad¹,

Parisa Mohagheghi²,

Karim Poorsattar Bejeh Mir³,

Arash Poorsattar Bejeh Mir^4,*

1Firoozgar Clinical Research Development Center, Tehran University of Medical Sciences, Tehran, Iran

2Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran

3Amir Mazandarani Hospital, Sari, Iran

4Department of Pediatrics, Tehran University of Medical Sciences, Tehran & Student Research Committee, Babol University of Medical Sciences, Babol, Iran

IJ Pediatrics:Vol. 22, issue 3; 375-384

Published online:Sep 30, 2012

Article type:Research Article

Received:Dec 13, 2010

Accepted:Sep 25, 2011

How to Cite:Seyed-Mohammad FereshtehnejadParisa MohagheghiKarim Poorsattar Bejeh MirArash Poorsattar Bejeh MirNew Predictors for Advanced Retinopathy of Prematurity among Neonates in Tehran/Iran.Iran J Pediatr.22(3):375-384.

Abstract

Objective: Since a new epidemic (third wave) of retinopathy of prematurity (ROP) sensed throughout the world in recent years, we aimed to assess newer risk factors for advanced ROP which needs treatment in Iranian neonates as a new target output of various neonatal care for this serious disease of newborn infants especially those born prematurely.
Methods:In an analytic cross-sectional study all neonates <1500 g birth weight and/or <32 weeks gestational age admitted to our NICU as a tertiary level intensive care unit in Milad Hospital, Tehran, Iran during June 2006-June 2007 were included. All data were extracted from medical records and compared in two groups with or without treatment.
Findings:Seventy one neonate infants entered our study. Twelve neonates (16.9%) progressed to advanced ROP. Final multivariate analysis model revealed that mean leukocyte counts during first 14 days of life (P=0.04), transfusions number (P=0.01) and hypocapnic episodes during first 14 days of life (P=0.02) were significantly different between the two groups of infants independently, even after simultaneous adjustment.
Conclusion:Based on our findings, more amenable risk factors should be approached regarding more careful modulation of such overlooked risk factors which may lessen the burden of prematurity.

Keywords

Neonate

Retinal Surgery

Retinopathy of Prematurity

Risk Factor

Very Low Birth Weight

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