Beneficial Effect of Cyproheptadine on Body Mass Index in Undernourished Children: A Randomized Controlled Trial

Mozhgan Moghtaderi; Khadijehsadat  Najib; Zohreh  Karamizadeh; Ebrahim  Fallahzadeh

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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Beneficial Effect of Cyproheptadine on Body Mass Index in Undernourished Children: A Randomized Controlled Trial

Author(s):

Mozhgan Moghtaderi^1,*,

Khadijehsadat Najib²,

Zohreh Karamizadeh³,

Ebrahim Fallahzadeh⁴

IJ Pediatrics:Vol. 24, issue 6; 753-758

Published online:Dec 12, 2014

Article type:Research Article

Received:Dec 28, 2013

Accepted:Nov 11, 2014

How to Cite:Mozhgan MoghtaderiKhadijehsadat NajibZohreh KaramizadehEbrahim FallahzadehBeneficial Effect of Cyproheptadine on Body Mass Index in Undernourished Children: A Randomized Controlled Trial.Iran J Pediatr.24(6):753-758.

Abstract

Objective: Cyproheptadine hydrochloride (CH) is a first-generation antihistamine which is used as an appetite stimulant. This study was designed to identify the role of CH therapy on weight gain, linear growth and body mass index in children with mild to moderate undernutrition. Methods: Eighty-nine patients were enrolled. The present randomized, double-blinded controlled trial included 77 evaluable patients, aged 24-64 months with undernutrition. The patients were randomized to receive cyproheptadine with multivitamin, or multivitamin over a period of four weeks. The weight, height and body mass index were measured at the baseline, four weeks after intervention and four weeks after discontinuation. Findings: A significant higher body mass index was observed among CH-treated patients after 8 weeks intervention with cyproheptadine compared with the control group (P

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