The effect of progressive resistance training with melatonin supplementation on total antioxidant capacity and lipid peroxidation in overweight men, randomized clinical trial

Introduction: The purpose of present study was to investigate the effect of progressive resistance training with melatonin supplementation on plasma total antioxidant capacity and lipid peroxidation in overweight men.

Methods: In this clinical trial, 40 men with body mass index (BMI) between 25-30 were randomly divided into into four groups: training-supplement (N=10), training-placebo (N=10), supplement (N=10), and placebo (N=10). The training group performed an progressive resistance training session, 3 sessions each week with 55-85% 1RM for 8 weeks. The treatment groups received three mg of melatonin in capsule form every day two hours before bedtime. Data were statistically analyzed by ANCOVA and post-hoc Bonferroni methods (p≤0.05).

Results: The results showed that resistance training with melatonin consumption significantly increased TAC in training-supplement (p≤0.007), training-placebo (p≤0.029), supplement (p≤0.025) groups. However, significantly increased MDA values only in training-supplement (p≤0.039) and supplement (p≤0.048) groups.However, no significant changes were observed in the training-placebo and control groups (P> 0.05). The results of the intergroup differences indicated that TAC was significant only between the training-supplement, training-placebo and control groups (p≤0.05). groups. While there was no significant difference in MDA values between the training-supplement, training-placebo, supplement and placebo groups ​​(P> 0.05).

 Conclusion: Supplementation of melatonin alone and in combination with resistance training has been more effective due to potent antioxidant anti-inflammatory effects, can would improve the antioxidant capacity in overweight men