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Prevalence of Extended-Spectrum Beta-lactamases (ESBLs) in Pseudomonas aeruginosa Isolated from Hospitalized Patients in Imam Reza and Imam Khomeini hospitals in Kermanshah, 2013‎

AUTHORS

avatar Fardin Zoghi Maleki‎ 1 , avatar Mohammad Reza Nahaei‎ 2 , * , avatar Nasrollah Sohrabi‎ 3 , avatar Laya Rezavand‎ 4

1 Faculty of Basic Sciences,‎‏ ‏Ahar Islamic of Azad‏ ‏University, Ahar‎, Iran

2 Department of‏ ‏Microbiology, School of‏ ‏Medicine, Tabriz University‏ ‏of Medical Sciences, ‎Tabriz‎, Iran

3 Department of Medical‏ ‏Laboratory Sciences, School‏ ‏of Paramedicine,‎‏ ‏Kermanshah ‎University of‏ ‏Medical Sciences,‎‏ ‏Kermanshah, Iran

4 Kermanshah University of‏ ‏Medical Sciences,‎‏ ‏Kermanshah‎, Iran

How to Cite: Zoghi Maleki‎ F , Nahaei‎ M R , Sohrabi‎ N , Rezavand‎ L . Prevalence of Extended-Spectrum Beta-lactamases (ESBLs) in Pseudomonas aeruginosa Isolated from Hospitalized Patients in Imam Reza and Imam Khomeini hospitals in Kermanshah, 2013‎. J Clin Res Paramed Sci. 2015;4(3):e82033.

ARTICLE INFORMATION

Journal of Clinical Research in Paramedical Sciences: 4 (3); e82033
Published Online: October 10, 2015
Article Type: Research Article
Received: January 05, 2015
Accepted: August 13, 2015
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Abstract

Background: Pseudomonas aeruginosa is one of the most common Gram negative bacteria involved in nosocomial infections. Presence of Extended-spectrum Beta-lactamases (ESBLs) genes, play an important role in induction of resistance in beta-lactamase  producing species to beta lactam antibiotics. Frequency of resistance to these antibiotics is increasing. In this study, antibiotic sensitivity and frequency of ESBLs in Pseudomonas aeruginosa which had been isolated from clinical specimens, was assessed by phenotypic
methods.
Methods: This study was performed on 200 isolated Pseudomonas aeruginosa from clinical specimens in Imam Khomeini and Imam Reza hospitals, Kermanshah during 2013. Specimens were determined and cultured by standard conventional methods. Antibiotic sensitivity test on 14 antibacterial agents was performed according to CLSI criteria.
Then, frequency of ESBLs producing isolates was determined by Combined Disk Test (CDT) and Double Disk Synergy Test (DDST) methods.
Results: This study revealed that the highest and lowest resistance rate were against to cefpodoxime (100%) and piperacilin-tazobactam (34%), respectively. Using CDT and DDST methods, 41% of isolates were ESBL positive.
Conclusion: Considering high resistance rate of Pseudomonas aeruginosa to majority of antibiotics and increasing frequency of ESBLs producing isolates, we need for infection control criteria and use of appropriate therapeutic protocols according to antibiogram
test patterns.
 

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© 2015, Journal of Clinical Research in Paramedical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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