The Common Human Papillomavirus Genotypes among Cervical pre-cancerous and cancerous samples in Kermanshah Province (2013)

Tayebeh Vaezi; Zabihollah Shoja; Shohreh Shahmahmoodi; Farhad Babaei; Babak Izadi; Somayeh Jalilvand

doi:10.22110/jkums.v21i1.3479

Journal of Kermanshah University of Medical Sciences

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https://doi.org/10.22110/jkums.v21i1.3479

The Common Human Papillomavirus Genotypes among Cervical pre-cancerous and cancerous samples in Kermanshah Province (2013)

Author(s):

Tayebeh Vaezi¹,

Zabihollah Shoja²,

Shohreh Shahmahmoodi³,

Farhad Babaei⁴,

Babak Izadi⁵,

Somayeh Jalilvand^1,*

1Dept. of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

2Dept. of Virology, Pasteur Institute of Iran, Tehran, Iran

3Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, Iran

4Dept. of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

5Dept. of Pathology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

Journal of Kermanshah University of Medical Sciences:Vol. 21, issue 1; e69511

Published online:May 31, 2017

Article type:Research Article

Received:Feb 21, 2017

Accepted:May 27, 2017

How to Cite:Tayebeh VaeziZabihollah ShojaShohreh ShahmahmoodiFarhad BabaeiBabak IzadiSomayeh Jalilvandet al.The Common Human Papillomavirus Genotypes among Cervical pre-cancerous and cancerous samples in Kermanshah Province (2013).J Kermanshah Univ Med Sci.21(1):e69511.https://doi.org/10.22110/jkums.v21i1.3479.

Abstract

Introduction: It is important to have data on human papillomavirus (HPV) from different geographical regions of Iran for health policymakers to make decisions on national programs of HPV vaccination. Because no study was found on HPV genotyping in Kermanshah Province, this study appeared necessary.

Methods: Fifty-three paraffin-embedded cervical tissue samples were collected. All samples were evaluated by polymerase chain reaction (PCR) or nested-polymerase chain reaction assays with specific primers designed for L1 gene. Positive samples were subjected to sequence and phylogenic tree analysis.

Results: Thirty-one out of 53 samples (58.5%) were found to be HPV positive. Prominent HPV genotype was HPV16 followed by HPV6, 31 and 53. Based on the histology of cervicitis, only HPV16 was found both in cervicitis and adenocarcinoma while HPV6 and 16 were found in cervical intraepithelial neoplasia I, and HPV6 and 53 were found in cervical intraepithelial neoplasia II. HPV16 and 31 were also found in squamous cell carcinoma.

Discussion: Findings from this study support a strong correlation of HPV16 as a leading cause of cervical cancer in this region. It appears that HPV vaccines could drastically reduce the incidence of cervical cancer.

Keywords

Cervical Cancer

Papillomavirus

Genotype

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Author(s):

Tayebeh Vaezi:[PubMed][Scholar]
Zabihollah Shoja:[PubMed][Scholar]
Shohreh Shahmahmoodi:[PubMed][Scholar]
Farhad Babaei:[PubMed][Scholar]
Babak Izadi:[PubMed][Scholar]
Somayeh Jalilvand:[PubMed][Scholar]