The Common Human Papillomavirus Genotypes among Cervical pre-cancerous and cancerous samples in Kermanshah Province (2013)

authors:

avatar Tayebeh Vaezi 1 , avatar Zabihollah Shoja 2 , avatar Shohreh Shahmahmoodi 3 , avatar Farhad Babaei 4 , avatar Babak Izadi 5 , avatar Somayeh Jalilvand 1 , *

Dept. of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Dept. of Virology, Pasteur Institute of Iran, Tehran, Iran
Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, Iran
Dept. of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Dept. of Pathology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

how to cite: Vaezi T, Shoja Z, Shahmahmoodi S, Babaei F, Izadi B, et al. The Common Human Papillomavirus Genotypes among Cervical pre-cancerous and cancerous samples in Kermanshah Province (2013). J Kermanshah Univ Med Sci. 2017;21(1):e69511. doi: 10.22110/jkums.v21i1.3479.

Abstract

Methods: Fifty-three paraffin-embedded cervical tissue samples were collected. All samples were evaluated by polymerase chain reaction (PCR) or nested-polymerase chain reaction assays with specific primers designed for L1 gene. Positive samples were subjected to sequence and phylogenic tree analysis.
Results: Thirty-one out of 53 samples (58.5%) were found to be HPV positive. Prominent HPV genotype was HPV16 followed by HPV6, 31 and 53. Based on the histology of cervicitis, only HPV16 was found both in cervicitis and adenocarcinoma while HPV6 and 16 were found in cervical intraepithelial neoplasia I, and HPV6 and 53 were found in cervical intraepithelial neoplasia II. HPV16 and 31 were also found in squamous cell carcinoma.
Discussion: Findings from this study support a strong correlation of HPV16 as a leading cause of cervical cancer in this region. It appears that HPV vaccines could drastically reduce the incidence of cervical cancer.

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