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The effects of repeated cyanide injection on rat's heart resistance against ischemia

AUTHORS

avatar D Shakibaaii 1 , * , avatar M Na'leini 1 , avatar AA NejaatiSafaa 1

1 Iran

How to Cite: Shakibaaii D, Na'leini M, NejaatiSafaa A. The effects of repeated cyanide injection on rat's heart resistance against ischemia. J Kermanshah Univ Med Sci. 2002;6(3):e81012.

ARTICLE INFORMATION

Journal of Kermanshah University of Medical Sciences: 6 (3); e81012
Published Online: December 19, 2002
Article Type: Research Article
Received: August 12, 2002
Accepted: December 11, 2002
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Abstract

Introduction and Objectives: Since cyanide is a strong inhibitor of cytochrome oxidase and metabolism , we need to know whether it is useful in increasing cardiac resistance to ischemia.
 Materials and Methods: Male rats received either 1.7mg/kg potassium cyanide or normal saline transperitoneally for 35 days. Then, isolated hearts were examined at baseline, during ischemia and after return to normal perfusion state..
 Results: Coronary blood flow, left ventricular pressure and contractility (dp/dt) were similar in two groups, but at  ischemic state (p<0.005) and at recovery to normal   state(p<0.05)   there were  statistically significant differences in left ventricular pressure and contractility (dp/dt) between the two groups. 
Discussion and Conclusions: It seams that cyanide induce cardiac resistance to ischemic effects in rats.

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© 2002, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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