Fulltext
`The full text of this article is available on PDF
Journal of Kermanshah University of Medical Sciences
Peer-reviewed Medical Quarterly
e-ISSN 2588-2570
p-ISSN 2588-2562
The effects of repeated cyanide injection on rat's heart resistance against ischemia
Authors
1Iran
Published online:Dec 19, 2002
Article type:Research Article
Received:Aug 12, 2002
Accepted:Dec 11, 2002
How to Cite:Shakibaaii D, Na'leini M, NejaatiSafaa A. The effects of repeated cyanide injection on rat's heart resistance against ischemia. J Kermanshah Univ Med Sci. 2002;6(3):e81012. doi:
Abstract
Introduction and Objectives: Since cyanide is a strong inhibitor of cytochrome oxidase and metabolism , we need to know whether it is useful in increasing cardiac resistance to ischemia.
Materials and Methods: Male rats received either 1.7mg/kg potassium cyanide or normal saline transperitoneally for 35 days. Then, isolated hearts were examined at baseline, during ischemia and after return to normal perfusion state..
Results: Coronary blood flow, left ventricular pressure and contractility (dp/dt) were similar in two groups, but at ischemic state (p<0.005) and at recovery to normal state(p<0.05) there were statistically significant differences in left ventricular pressure and contractility (dp/dt) between the two groups.
Discussion and Conclusions: It seams that cyanide induce cardiac resistance to ischemic effects in rats.
Copyright
© 2002, Journal of Kermanshah University of Medical Sciences. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
Similar Articles
31
Jan
2012
Nitric Oxide is Necessary for Diazoxide Protection Against Ischemic Injury in Skeletal Muscle
Hossein Farahini,
Marjan Ajami,
Jalaledin Mirzay Razaz,
Nahid Azad,
Mansooreh Soleimani,
Seyyed Abdulmajid Ayatollahi
,et al.Farahini H, Ajami M, Mirzay Razaz J, Azad N, Soleimani M, et al. Nitric Oxide is Necessary for Diazoxide Protection Against Ischemic Injury in Skeletal Muscle. Iran J Pharm Res. 2012;11(1):e125777. doi: https://doi.org/10.22037/ijpr.2012.1091
30
Sep
2012
Cardioprotective effect of fasting on ischemia reperfused rat heart after diazepam administration
Dareuosh Shackebaei,
Sima Nasri,
Soheila Ebrahimi Vosta Kalaee,
Mitra Azadi Miankouhi,
Mahvash Hesari
Shackebaei D, Nasri S, Ebrahimi Vosta Kalaee S, Azadi Miankouhi M, Hesari M. Cardioprotective effect of fasting on ischemia reperfused rat heart after diazepam administration. Int Cardiovasc Res J. 2017;6(1):e12845. doi:
31
Oct
2012
Acute Administration of Natural Honey Protects Isolated Heart in Normothermic Ischemia
Afshin Gharekhani,
Moslem Najafi,
Hamed Ghavimi
Gharekhani A, Najafi M, Ghavimi H. Acute Administration of Natural Honey Protects Isolated Heart in Normothermic Ischemia. Iran J Pharm Res. 2012;11(4):e125885. doi: https://doi.org/10.22037/ijpr.2012.1131
1
Jun
2016
The Effect of Diazepam on the Function of Hypertrophied Rats’ Hearts in Ischemia-Reperfusion Conditions
Dareuosh Shackebaei,
Farid Feizollahi,
Mahvash Hesari,
Gholamreza Bahrami
Shackebaei D, Feizollahi F, Hesari M, Bahrami G. The Effect of Diazepam on the Function of Hypertrophied Rats’ Hearts in Ischemia-Reperfusion Conditions. Int Cardiovasc Res J. 2016;10(2):e10285. doi:
18
Apr
2015
Role of nitric-oxide in cardiac effects of glibenclamide in rat
F Mirershadi,
H Ogagzadeh,
Mahdiye Faghihi,
leila Alizadeh
Mirershadi F, Ogagzadeh H, Faghihi M, Alizadeh L. Role of nitric-oxide in cardiac effects of glibenclamide in rat. J Inflamm Dis. 2024;19(1):e155886. doi:
Cited by
- Scopus by DOI: 0
Last Update: 1 month ago
- Scopus by Title: 0
Last Update: 1 month ago
- Scopus by Title (Ref): 0
Last Update: 1 month ago
- CrossRef: 0
Last Update: 1 day ago
Comments
Number of Comments:0