Protective Effect Hydroalcoholic Extract Allium Jesdianum Boiss against Ccl4-Induced Hepatotoxicity in Male Mice

Heibatullah Kalantari; Esmat Keshavarzi; Parvin Kheradmand; Maedeh Goodarzian; Leila Zeidooni

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Protective Effect Hydroalcoholic Extract Allium Jesdianum Boiss against Ccl4-Induced Hepatotoxicity in Male Mice

Author(s):

Heibatullah Kalantari^{1, 2},

Esmat Keshavarzi²,

Parvin Kheradmand³,

Maedeh Goodarzian³,

Leila Zeidooni

^{2, 4,*}

1Medicinal Plants Research Center, Ahvaz, Iran

2Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

3Department of Pathology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

4Department of Toxicology, School of Pharmacy, Ahvaz, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 7, issue 3; 389-399

Published online:Nov 04, 2018

Article type:Research Article

Received:Aug 25, 2018

Accepted:Oct 24, 2018

How to Cite:Heibatullah KalantariEsmat KeshavarziParvin KheradmandMaedeh GoodarzianLeila ZeidooniProtective Effect Hydroalcoholic Extract Allium Jesdianum Boiss against Ccl4-Induced Hepatotoxicity in Male Mice.J Rep Pharm Sci.7(3):e147507.

Abstract

Allium Jesdianum Boiss (Allium) has many pharmacological beneficial effects. However, its protective effects against hepatotoxicity induced by carbon tetrachloride (CCl4) have not been explained. The present study was undertaken to investigate the protective effects of Allium on liver oxidative stress in male mice treated to CCl4. Forty-two male mice were randomly divided into six groups. Control group, sham group, CCl4 group, Allium 500 mg/kg + CCl4, Allium 1000 mg/kg + CCl4, Allium 2000 mg/kg + CCl4. Results showed that CCl4 significantly increased serum levels of alanine aminotransferase, aspartate aminotransferase, lipid peroxidation and decreased catalase activity and glutathione level, and also caused inflammation, coagulative necrosis, degeneration of hepatocytes, fatty change, and dilated sinosouids in liver tissue. While administration of Allium at the all doses used significantly altered all examined endpoints that induced by CCl4. Overall, our findings suggest that Allium possesses hepatoprotective effects against CCl4-induced hepatotoxicity by suppressing oxidative stress and improving the antioxidative defense system.

Keywords

Allium Jesdianum Boiss

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