Evaluation of In Vitro Antimicrobial and Antioxidant Activities of 4 -Substituted- 1,2 ,4 -Triazolidine-3 ,5 -Dione Derivatives

Hadi Adibi; Ramin Abiri; Shadpour Mallakpour; Mohammad Ali Zolfigol; Mohammad Bagher Takhtshahi

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Evaluation of In Vitro Antimicrobial and Antioxidant Activities of 4 -Substituted- 1,2 ,4 -Triazolidine-3 ,5 -Dione Derivatives

Author(s):

Hadi Adibi¹,

Ramin Abiri

²,

Shadpour Mallakpour³,

Mohammad Ali Zolfigol⁴,

Mohammad Bagher Takhtshahi^5,*

1Novel Drug Delivery Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran

2Department of Microbiology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

3Organic Polymer Chemistry Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan, Iran

4Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran

5Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, and Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 1, issue 2; 87-93

Published online:Dec 29, 2012

Article type:Research Article

Received:Oct 03, 2012

Accepted:Oct 26, 2012

How to Cite:Hadi AdibiRamin AbiriShadpour MallakpourMohammad Ali ZolfigolMohammad Bagher TakhtshahiEvaluation of In Vitro Antimicrobial and Antioxidant Activities of 4 -Substituted- 1,2 ,4 -Triazolidine-3 ,5 -Dione Derivatives.J Rep Pharm Sci.1(2):e147769.

Abstract

In a wide search program towards new and efficient antimicrobial agents, a series of 4-substituted-1,2,4-triazolidine-3,5-dione derivatives namely uraz- oles holding an alkyl moiety at position 4 have been synthesized and tested for their in vitro antibacterial and antifungal activities. The structures of these compounds have been investigated by spectral data. The synthesized compounds were tested in vitro against two Gram-positive, six Gram-negative bacteria, and the yeast Candida albicans (clinical isolated) in comparison with several control drugs. The antioxidant activity of the tested compounds was also assessed by 2 tests highly documented in the literature: capability to prevent lipid peroxidation, and direct scavenging effect on a stable free radical, 1,l-diphenyl-2-picryl-hydrazide (DPPH).

Keywords

antibacterial activity

Antifungal activity

antioxidant activity

Triazolidinediones

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