Evaluation of In Vitro Antimicrobial and Antioxidant Activities of 4 -Substituted- 1,2 ,4 -Triazolidine-3 ,5 -Dione Derivatives

authors:

avatar Hadi Adibi 1 , avatar Ramin Abiri ORCID 2 , avatar Shadpour Mallakpour 3 , avatar Mohammad Ali Zolfigol 4 , avatar Mohammad Bagher Takhtshahi 5 , *

Novel Drug Delivery Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
Department of Microbiology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Organic Polymer Chemistry Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan, Iran
Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran
Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, and Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Journal of Reports in Pharmaceutical Sciences: Vol.1, issue 2; 87-93
published online: December 29, 2012
article type: Research Article
received: October 03, 2012
revised: October 17, 2012
accepted: October 26, 2012

how to cite: Adibi H, Abiri R, Mallakpour S, Zolfigol M A, Takhtshahi M B. Evaluation of In Vitro Antimicrobial and Antioxidant Activities of 4 -Substituted- 1,2 ,4 -Triazolidine-3 ,5 -Dione Derivatives. J Rep Pharm Sci. 2012;1(2):e147769. 

Abstract

In a wide search program towards new and efficient antimicrobial agents, a series of 4-substituted-1,2,4-triazolidine-3,5-dione derivatives namely uraz- oles holding an alkyl moiety at position 4 have been synthesized and tested for their in vitro antibacterial and antifungal activities. The structures of these compounds have been investigated by spectral data. The synthesized compounds were tested in vitro against two Gram-positive, six Gram-negative bacteria, and the yeast Candida albicans (clinical isolated) in comparison with several control drugs. The antioxidant activity of the tested compounds was also assessed by 2 tests highly documented in the literature: capability to prevent lipid peroxidation, and direct scavenging effect on a stable free radical, 1,l-diphenyl-2-picryl-hydrazide (DPPH).