Effects of endurance training and six weeks of ginseng supplementation on serum vascular endothelial growth factor and platelet-derived growth factor in unathletes female students

authors:

avatar alireza barari , avatar asieh abbassi daloii , * , avatar ezzat douroki


how to cite: barari A, abbassi daloii A, douroki E. Effects of endurance training and six weeks of ginseng supplementation on serum vascular endothelial growth factor and platelet-derived growth factor in unathletes female students. koomesh. 2024;19(1):e151111. 

Abstract

Introduction: The aim of this study was to determine the effects of six weeks of endurance training and ginseng supplement consumption on vascular endothelial growth factor (VEGF) and platelet-derived growth factor levels in unathletes female student. Materials and Methods: In this study, 32 unathlete female students of Gorgan University (Iran) with the mean age of 20 ±2 years were randomly divided into endurance, endurance and ginseng, ginseng and control groups. Endurance training consisted of six weeks training with three sessions per week and each session was 70 minutes. The program of intermittent running was with intensity of 60-80% maximum heart rate. Ginseng extract was orally consumed (5 mg/kg/day for six weeks). Results: No significant effects of six weeks of endurance training together with ginseng supplement were found on the levels of VEGF (P

References

  • 1.

    Kordi M R, nekouei A, shafiee A, hadidi 4. The effect of eight weeks high intensity aerobic continuous and interval training on gene expression of vascular endothelial growth factor in soleus muscle of healthy male rats. Arak Univ Med Sci J 2015; 18: 53-62. (Persian).

  • 2.

    Egginton S. Invited review: activity-induced angiogenesis. Pflugers Arch 2009; 457: 963-977.

  • 3.

    Iversen N, Krustrup P, Rasmussen HN, Rasmussen UF, Saltin B, Pilegaard H. Mitochondrial biogenesis and angiogenesis in skeletal muscle of the elderly. Exp Gerontol 2011; 46: 670-678.

  • 4.

    Tsutsumi N, Yonemitsu Y, Shikada Y, Onimaru M, Tanii M, Okano S, et al. Essential role of PDGFRa-p70S6K signaling in mesenchymal cells during therapeutic and tumor angiogenesis in vivo: role of PDGFRa during angiogenesis. Circ Res 2004; 94: 1186-1194.

  • 5.

    Lindberg N, Holland EC. PDGF in gliomas: more than just a growth factor? Ups J Med Sci 2012; 117: 92-98.

  • 6.

    Hu SY. A contribution to our knowledge of ginseng. Am J Chin Med (Gard City N Y) 1977; 5: 1-23.

  • 7.

    Lidija BR, Zdenka KE, Ita S. The antidepressant activity of Hypericum perforatum L. measured by two experimental methods on mice. Acta Pharm 2004; 54: 157-162.

  • 8.

    Kim Y, Namkoong S, Yun Y, Hong H, Lee Y, Ha K, et al. Water extract of Korean red ginseng stimulates angiogenesis by activating the PI3K/Akt-dependent ERK1/2 and eNOS pathways in human umbilical vein endothelial cells. Biol Pharm Bull 2007; 30: 1674-1679.

  • 9.

    Lei Y, Tian W, Zhu L, Yang J, Chen K. Effects of Radix Ginseng and Radix Not ginseng formula on secretion of vascular endothelial growth factor and expression of vascular endothelial growth factor receptor-2 in human umbilical vein endothelial cells. Zhong Xi Yi Jie He Xue Bao 2010; 8: 368-372.

  • 10.

    Nourshahi M, Hedayati M, Nemati J, Ranjbar K, Gholamali M. Effect of 8 weeks endurance training on serum vascular endothelial growth factor and endostatin in Wistar rats. Koomesh 2012; 13: 474-479. (Persian).

  • 11.

    Bashiri J, Gaeini A, Hadi H. Endurance training affects muscular angiogenesis and serum VEGF concentration in diabetic rats. Koomesh 2015; 17: 123-132. (Persian).

  • 12.

    Iversen N, Krustrup P, Rasmussen HN, Rasmussen UF, Saltin B, Pilegaard H. Mitochondrial biogenesis and angiogenesis in skeletal muscle of the elderly. Exp Gerontol 2011; 46: 670-678.

  • 13.

    Nazarali P, Sini ZK, Kordi M. Effect of high-intensity interval training (HIIT) on vascular endothelial growth factor (VEGF) in heart muscle in healthy rats. Res J Fisher Hydrobiol 2015; 10: 118-122. (Persian).

  • 14.

    Czarkowska PB, Bartlomiejczyk I, Przybylski J. The serum levels of growth factors: PDGF, TGF-beta and VEGF are increased after strenuous physical exercise. J Physiol Pharmacol 2006; 57: 189-197.

  • 15.

    Barari A, Bashiri J, Sarabandi M. The effect of circuit resistance training combined with ginseng supplementation level of VEGF and PDGF in inactive females. Med J Tabriz Univ Med Sci Health Serv 2015; 37: 6-13. (Persian).

  • 16.

    Wakabayashi C, Murakami K, Hasegawa H, Murata J, Saiki I. An intestinal bacterial metabolite of ginsengprotopanaxadiol saponins has the ability to induce apoptosis in tumor cells. Biochem Biophys Res Commun 1998; 246: 725-730.

  • 17.

    Danzig V, Mikova B, Kuchynka P, Benakova H, Zima T, Kittnar O, et al. Levels of circulating biomarkers at rest and after exercise in coronary artery disease patients. Physiol Res 2010; 59: 385-392.

  • 18.

    Rullman D, Bischof P, Chardonnens D. Modulation of placental vascular endothelial growth factor by leptinand HCG. Mol Hum Reprod 2007; 9: 395-398.

  • 19.

    Milkiewicz M, Ispanovic E, Doyle JL, Haas TL. Regulators of angiogenesis and strategies for their therapeutic manipulation. Int J Biochem Cell Biol 2006; 38: 333-357.

  • 20.

    Gu JW, Gadonski G, Wang J, Makey I, Adair TH. Exercise increases endostatin in circulation of healthy volunteers. BMC Physiol 2004; PP: 1-6.

  • 21.

    Ranjbar K, Nourshahi M, Hedayati M, Taheri Chadorneshin H. Effect of gender and physical activity on serum vascular endothelial growth factor at rest and response to submaximal exercise. Iranian J Endocrinol and Metab 2011; 13: 294-300 (Persian).

  • 22.

    Suhr F, Rosenwick C, Vassiliadis A, Bloch W, Brixius K. Regulation of extracellular matrix compoundsinvolved in angiogenic processes in short- and longtrackelite runners. J Appl Physiol 2009; 261: 222-1223.##.

  • 23.

    Gavin TP, Stallings HW, Zwetsloot KA, Westekamp LM, Ryan NA, Moore RA, et al. Lower capillary density but no difference in VEGF expression in obese vs. lean young skeletal muscle in humans. J Appl Physiol 2004; 98: 315-321.

  • 24.

    Heidenreich R, Ricken M, Ghoreschi K. Angiogenesis: the new potential target for the therapy of psoriasis? Drug News Perspect 2008; 21: 97-105.

  • 25.

    Czarkowska-Paczek B, Zendzian-Piotrowska M, Bartlomiejczyk I, Przybylski J, Gorski J. Skeletal and heart muscle expression of PDGF-AA and VEGF-A after an acute bout of exercise and endurance training in rats. Med Sci Monit 2010; 16: BR147-153.

  • 26.

    Trenerry MK, Della Gatta PA, Larsen AE, Garnham AP, CameronSmith D. Impact of resistance exercise training on interleukin6 and JAK/STAT in young men. Muscle Nerve 2011; 43: 385-392.

  • 27.

    Jian-Wei Gu, Giovani G, Julie W, Ian M. Exercise increases endostatin in circulation of healthy volunteers. BMC Physiol 2004; 4: 1-6.

  • 28.

    Li X, Eriksson U. Novel VEGF family members: VEGF-B, VEGF-C and VEGF-D. Int J Biochem Cell Boil 2001; 3: 421-426.

  • 29.

    Olfert IM, Howlett RA, Dalton ND, Gu Y, Peterson KL, et al. Muscle-specific VEGF deficiency greatly reduces exercise endurance in mice. J Physiol 2009; 587: 1755-1767.

  • 30.

    Zeng D, Jinliang W, Peiyan K, Cheng Ch, Li J, Li J. Ginsenoside Rg3 inhibits HIF-1 and VEGF expression in patient with acute leukemia via inhibiting the activation of PI3K/Akt and ERK1/2 pathways. Int J Clin Exp Pathol 2014; 7: 2172-2178.

  • 31.

    Sun HQ, Yu Zhou Z. Effect of ginsenoside -Rg3 on the expression of VEGF and TNF- in retina with diabetic rats. J Pharmacol 2010; 165: 4-19##.