Authors
Nicolau syndrome also known as livedo-like dermatitis or embolia cutis medicamentosa is a rare adverse reaction of a still largely unidentified pathogenesis at the site of intramuscular and intra-articular drug injection.
herein we report a 7-year-old boy, a known case of cerebral palsy received a penicillin injection in the left buttock due to upper respiratory tract infection and one day later developed an echymotic, ischemic and necrotic area in the site of injection which extended to the left leg, thigh and foot gradually. Nicolau syndrome was diagnosed and the patient received prednisolone, pentoxyphyllin and was heparinized .In the follow up, the lesion began to improve.
There is no specific therapy for Nicolau syndrome other than prevention. Correct Intramuscular injections may prevent these conditions. This case is the second report of Nicolau syndrome from Iran after the case of Beheshti-rooy et al.
© 2010, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Deshmukh NS, Belgaumkar VA, Chavan RB, Bhatt N. Nicolau Syndrome Following Intralesional Sclerotherapy: A Dreaded Complication of a Simple Office Procedure. J Skin Stem Cell. 2020;7(3):e107198. doi: https://doi.org/10.5812/jssc.107198
Nikkhah A, Nikkhah A. Gradenigo’s Syndrome Without Facial Nerve Involvement in a Fourteen-Month-Old Girl. Jentashapir J Cell Mol Biol. 2014;5(4):e94073. doi:
Mosayebi Z, Omidian A, Movahedian AH, Kompani F, Hosseininodeh SS. Fournier’s Gangrene in a Neonate With Acute Myeloid Leukemia: A Case Report. Inn J Pediatr. 2016;26(3):e4537. doi: https://doi.org/10.5812/ijp.4537
Pakdel L, Ganji J. Necrotizing autoimmune myopathy: Muscle weakness due to atorvastatin. J Nurs Midwifery Sci. 2018;5(2):e141188. doi: https://doi.org/10.4103/jnms.jnms_17_18
Liana Rachisan A, Gheban D, Miu N. Cutaneous Sarcoid-Like Granulomas in a Child Known with Nijmegen Breakage Syndrome. Inn J Pediatr. 2013;23(1):. doi:
Last Update: 3 weeks ago
Last Update: 3 weeks ago
Last Update: 3 weeks ago
Last Update: 7 hours ago
Last Update: 1 day ago
Last Update: 4 days ago
