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Effect of Zinc Supplementation on Red Blood Cell Osmotic Fragility in hemodialysis Patients

Author(s):
J Roozbeh J Roozbeh 1, M Sharifian M Sharifian 2,*, M Karimi M Karimi 3, AR Hamidian Jahromi AR Hamidian Jahromi 4, R Afshariani R Afshariani 5
1Associate Professor, Section of Nephrology, Department of Internal Medicine and Urology Nephrology Research Centre,
2Student of Medicine,
3Professor, Section of hematology, Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran,
4Registrar, Department of Transplant Surgery, Renal Transplant Unit, St Georges Hospital, London, United Kingdom,
5Pediatrician, Department of Public Health, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran.


Shiraz E-Medical Journal:Vol. 10, issue 4; 186-9
Published online:Oct 01, 2009
Article type:Research Article
Received:Jun 24, 2009
Accepted:Aug 28, 2009
How to Cite:J Roozbeh M Sharifian M Karimi AR Hamidian Jahromi R Afshariani Effect of Zinc Supplementation on Red Blood Cell Osmotic Fragility in hemodialysis Patients.Shiraz E-Med J.10(4):186-9.

Abstract

Introduction:

Zinc deficiency may aggravate the effect of oxidative stress on RBC (Red Blood Cell) of chronic uremia. In this study, there is an attempt to show the relationship between the plasma zinc level and RBC osmotic fragility in hemodialysis patients.

Patients and Methods:

Thirty five patients with low level of serum zinc (serum zinc level

Results:

The mean serum zinc concentration among the participants increased and it was statistically significant (p<0.05). Erythrocytes at day 0 (59+/_ 3.5) were significantly (P < 0.05) more fragile in hypotonie saline than those at day 43(38+/_ 2.9), (at NaCl 40%). No significant changes were noted in the level of Hb

Discussion:

In this trial, oral zinc supplementation caused a significant rises in the plasma zinc level after 6 weeks. Although Hb concentration was not changed during the trial the level of osmotic fragility in red cells reduced significantly.

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