Effect of Partial Sleep Deprivation on Lipid Profile in High Fat Diet-Fed Rats in the Presence and Absence of Vitamin C

Hossein  Najafzadeh; Mohammad Kazem Gharib Naseri; Ali Shahriyari; Hamideh Akbari-Aliabad

Zahedan Journal of Research in Medical Sciences

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Effect of Partial Sleep Deprivation on Lipid Profile in High Fat Diet-Fed Rats in the Presence and Absence of Vitamin C

Author(s):

Hossein Najafzadeh^1,*,

Mohammad Kazem Gharib Naseri²,

Ali Shahriyari³,

Hamideh Akbari-Aliabad⁴

1Department of Pharmacology, Shahid Chamran University, Ahvaz, Iran

2Department of Physiology, Physiology Research Center, Joundishapour Medical University, Ahvaz, Iran

3Department of Biochemistry, Shahid Chamran University, Ahvaz, Iran

4Veterinarian, Ahvaz, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 15, issue 7; e92921

Published online:Jan 07, 2013

Article type:Research Article

Received:Aug 26, 2011

Accepted:Sep 10, 2012

How to Cite:Hossein NajafzadehMohammad Kazem Gharib NaseriAli ShahriyariHamideh Akbari-AliabadEffect of Partial Sleep Deprivation on Lipid Profile in High Fat Diet-Fed Rats in the Presence and Absence of Vitamin C.Zahedan J Res Med Sci.15(7):e92921.

Abstract

Background: The daily stress and shift working cause insomnia. In other hands, fatty food consumption increased this disorder. The aim of present study is evaluation additive effect of partial insomnia and high fatty diet with or without vitamin C on serum lipid profile in rats. Materials and Methods: Fifty six rats in 7 groups (8 rats each group) were conducted for study during 26 days as: 1: normal diet+normal sleep, 2: high fatty diet+normal sleep, 3: normal diet+insomnia, 4: high fatty diet+insomnia, 5: high fatty diet+normal sleep+vitamin C, 6: high fatty diet+insomnia+vitamin C, 7: normal diet+insomnia+ vitamin C. The lipid profile was examined at end of study. Results: Results shown the high fatty diet+insomnia increased triglyceride, LDL, VLDL level and decreased HDL level with comparison to high fatty diet+normal sleep group. But only insomnia did not change serum lipid profile. High fatty diet increased level of cholesterol (p<0.05). The normal diet increased body weight but high fatty diet decreased it significantly. Liver weight ratio was elevated by high fatty diet+insomnia. The vitamin C decreased cholesterol and increased HDL level in group of rats which received high fatty diet+insomnia. Conclusion: In conclusion, the present study shown the only insomnia did not affect on serum lipid profile while insomnia along with high fatty diet increased lipid high risk factors in blood.

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