The Application of Theta Burst Stimulation in Negative Symptoms of Patients with Schizophrenia

Reza Kazemi; Reza Rostami; Marco Antonio Marcolin; Sanaz Khomami; Mohammad-Reza Khodaei

Zahedan Journal of Research in Medical Sciences

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The Application of Theta Burst Stimulation in Negative Symptoms of Patients with Schizophrenia

Author(s):

Reza Kazemi^1,*,

Reza Rostami¹,

Marco Antonio Marcolin²,

Sanaz Khomami³,

Mohammad-Reza Khodaei⁴

1Department of Psychology, Faculty of Psychology and Educational Sciences, University of Tehran, Tehran, Iran

2Department of Psychiatry, Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil

3Department of Psychology, Faculty of Psychology and Educational Sciences, University of Shahid Chamran, Ahvaz, Iran

4Department of Psychiatry, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 14, issue 10; e93202

Published online:Oct 24, 2012

Article type:Brief Report

Received:Jan 11, 2012

Accepted:Feb 14, 2012

How to Cite:Reza KazemiReza RostamiMarco Antonio MarcolinSanaz KhomamiMohammad-Reza KhodaeiThe Application of Theta Burst Stimulation in Negative Symptoms of Patients with Schizophrenia.Zahedan J Res Med Sci.14(10):e93202.

Abstract

Background : The aim of this research is study of theta burst stimulation on left dorsolateral prefrontal cortex in remission of negative symptoms in patients with schizophrenia.
Materials and Methods : In a placebo, double blind and randomized study, 10 patients with schizophrenia assigned in experimental and control group. The experimental group received 20 sessions of TBS with 50 Hz frequency, but control group were treated just with sham coil. All the patients were appraised before, the 10th sessions and after the treatment. The treatment efficacy was calculated with ANOVA.
Results : The results indicated that the experimental group had statistical difference to control group in negative symptoms (p>0.007) and social functioning (p>0.01). But there weren’t any significant difference in quality of life and depression between two groups.
Conclusion : Theta burst stimulation can be mentioned as an efficacious treatment for people with schizophrenia.

Keywords

Transcranial magnetic

Stimulation

Schizophrenia

Prefrontal Cortex

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