Persistance of HBsAg and serum activities of liver enzymes among chronic carriers of hepatitis B

Mansoure Momen heravi; Hossein Akbari

Zahedan Journal of Research in Medical Sciences

The Official Journal of Zahedan University of Medical Sciences

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Persistance of HBsAg and serum activities of liver enzymes among chronic carriers of hepatitis B

Author(s):

Mansoure Momen heravi^1,*,

Hossein Akbari²

1Asistant professor of infectious diseases, Kashan University of Medical Sciences and Health Services, Kashan, Iran

2Instructor of Biostatistics, School of Health, Kashan University of Medical Sciences and Health Services, Kashan, Iran.

Zahedan Journal of Research in Medical Sciences:Vol. 13, issue 3; e94013

Published online:Jan 01, 2011

Article type:Research Article

Received:Apr 13, 2010

Accepted:Oct 19, 2010

How to Cite:Mansoure Momen heraviHossein AkbariPersistance of HBsAg and serum activities of liver enzymes among chronic carriers of hepatitis B.Zahedan J Res Med Sci.13(3):e94013.

Abstract

Background: Hepatitis B virus (HBV) infection and its squeals are major global health problems. This study was conducted to evaluate HBsAg persistence, risk factors of HBV infection and changes of liver function tests among chronic HBV carriers in Kashan.

Materials and Method: This descriptive study was performed in HBsAg positive blood donors who detected after blood donation since 10 years ago. They were requested to retest HBsAg. A questionnaire consisting demographic and history of risk factors of HBV infection were filled by interviewing and then blood was taken for HBsAg test. Who had HBsAg positive test HBeAg, liver function tests were measured. The results were analyzed χ², Fisher exact and t-tests using SPSS-13 software.

Results: A total of 150 HBsAg positive blood donors persistence of HBsAg in 88% and clearance was seen in 12% of cases. There was no significant statistical correlation between risk factors of HBV infection, with persistence of HBsAg.

HBeAg was positive in 18.2% of HBsAg positive cases. There was no statistical correlation between ALT, AST and ALP with HBeAg. Chronic hepatitis B infection was detected in three patients.

Conclusion: Considering the lower rate of clearance of HBsAg and detecting cases of chronic hepatitis periodic examination of liver function tests seems to be essential in follow up in chronic HBV carriers

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