Abstract
Background:Lactation failing is one of the leads to infants weight loss and illness. Vary degree of
success have been reported with many strategies to increase milk production when it is failed. This
study was investigated the effect of Domperidone in augmentation milk production
Materials and Methods: In a double blind placebo controlled trial 48 mothers that their infants
were under grow square and it was due to mothers milk not enough, randomly was divided to two
groups : 24 received Domperidone 10mg TDS orally for 14 days and 24 received placebo ( the
same shape) TDS orally for 14 days. Milk volume was measured the day before study on day 7, 14
and one week after study; and serum prolactin level was measured the day before study, day 14 and
one week after the study. SPSS 11.5 software was used to analyze the results with Q square test and
T student test; and P< 0.05 was significantly difference.
Results: Data obtained from two group of study indicated treatment with Domperidone
increased the volume of milk amount 48.5 ml compared 8 ml in treatment with placebo.(P= 0.008)
also serum prolactin was raised 116.4 ng/ml in Domperidone group compared with 4ng/ml in
placebo group (P=0.001)
Discussion: Domperidone is an effective drug in milk production increasing and serum
prolactin.
success have been reported with many strategies to increase milk production when it is failed. This
study was investigated the effect of Domperidone in augmentation milk production
Materials and Methods: In a double blind placebo controlled trial 48 mothers that their infants
were under grow square and it was due to mothers milk not enough, randomly was divided to two
groups : 24 received Domperidone 10mg TDS orally for 14 days and 24 received placebo ( the
same shape) TDS orally for 14 days. Milk volume was measured the day before study on day 7, 14
and one week after study; and serum prolactin level was measured the day before study, day 14 and
one week after the study. SPSS 11.5 software was used to analyze the results with Q square test and
T student test; and P< 0.05 was significantly difference.
Results: Data obtained from two group of study indicated treatment with Domperidone
increased the volume of milk amount 48.5 ml compared 8 ml in treatment with placebo.(P= 0.008)
also serum prolactin was raised 116.4 ng/ml in Domperidone group compared with 4ng/ml in
placebo group (P=0.001)
Discussion: Domperidone is an effective drug in milk production increasing and serum
prolactin.
Keywords
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Copyright
© 2007, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.