Comparison of effect of Domperidone and placebo on human milk production

L sekhavat; fatemeh zarei; Sedighah  Akhavan Karbasi

Zahedan Journal of Research in Medical Sciences

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Comparison of effect of Domperidone and placebo on human milk production

Author(s):

L sekhavat^1,*,

fatemeh zarei¹,

Sedighah Akhavan Karbasi²

1Dept of Midwifery and Genicology, Faculty of Medicine, Shahid Sadooghy University of Medical Sciences and Health Services, Yazd, Iran.

2Dept of Pediatrics, Faculty of Medicine, Shahid Sadooghy University of Medical Sciences and Health Services, Yazd, Iran.

Zahedan Journal of Research in Medical Sciences:Vol. 9, issue 4; e94773

Published online:Jun 17, 2008

Article type:Research Article

Received:Dec 22, 2007

Accepted:Apr 07, 2007

How to Cite:L sekhavatfatemeh zareiSedighah Akhavan KarbasiComparison of effect of Domperidone and placebo on human milk production.Zahedan J Res Med Sci.9(4):e94773.

Abstract

Background:Lactation failing is one of the leads to infants weight loss and illness. Vary degree of
success have been reported with many strategies to increase milk production when it is failed. This
study was investigated the effect of Domperidone in augmentation milk production
Materials and Methods: In a double blind placebo controlled trial 48 mothers that their infants
were under grow square and it was due to mothers milk not enough, randomly was divided to two
groups : 24 received Domperidone 10mg TDS orally for 14 days and 24 received placebo ( the
same shape) TDS orally for 14 days. Milk volume was measured the day before study on day 7, 14
and one week after study; and serum prolactin level was measured the day before study, day 14 and
one week after the study. SPSS 11.5 software was used to analyze the results with Q square test and
T student test; and P< 0.05 was significantly difference.
Results: Data obtained from two group of study indicated treatment with Domperidone
increased the volume of milk amount 48.5 ml compared 8 ml in treatment with placebo.(P= 0.008)
also serum prolactin was raised 116.4 ng/ml in Domperidone group compared with 4ng/ml in
placebo group (P=0.001)
Discussion: Domperidone is an effective drug in milk production increasing and serum
prolactin.

Keywords

Human milk

Serum prolactin

Domperidone

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