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131 resultsUpdated November 11, 2026
1

Prebiotics and probiotics for depression and anxiety: A systematic review and meta-analysis of controlled clinical trials

Neuroscience & Biobehavioral Reviews 102 (2019)

Richard T. Liu; Rachel F.L. Walsh; Ana E. Sheehan

2

Gut microbiota and major depressive disorder: A systematic review and meta-analysis

Journal of Affective Disorders 266 (2020)

Kenji Sanada; Shinichiro Nakajima; Shunya Kurokawa; Alberto Barceló‐Soler; Daisuke Ikuse; Akihito Hirata; Akira Yoshizawa; Yoshihiro Tomizawa; Montserrat Salas Valero; Yoshihiro Noda; Masaru Mimura; Akira Iwanami; Taishiro Kishimoto

3

Gut-brain Axis and migraine headache: a comprehensive review

The Journal of Headache and Pain 21(1) (2020)

Mahsa Arzani; Soodeh Razeghi Jahromi; Zeinab Ghorbani; Fahimeh Vahabizad; Paolo Martelletti; Amir Ghaemi; Simona Sacco; Mansoureh Togha

4

Clinical, gut microbial and neural effects of a probiotic add-on therapy in depressed patients: a randomized controlled trial

Translational Psychiatry 12(1) (2022)

Anna-Chiara Schaub; Else Schneider; Jorge Francisco Vázquez-Castellanos; Nina Schweinfurth; Cedric Kettelhack; Jessica P. K. Doll; Gulnara Yamanbaeva; Laura Mählmann; Serge Brand; Christoph Beglinger; Stefan Borgwardt; Jeroen Raes; André Schmidt; Undine Emmi Lang

5

The role of probiotics and prebiotics in modulating of the gut-brain axis

Frontiers in Nutrition 10 (2023)

Fereshteh Ansari; Mehrdad Neshat; Hadi Pourjafar; Seid Mahdi Jafari; Shohreh Alian Samakkhah; Esmaeel Mirzakhani

6

Antidepressive Mechanisms of Probiotics and Their Therapeutic Potential

Frontiers in Neuroscience 13 (2020)

Shin Jie Yong; Tommy Tong; Jactty Chew; Wei Ling Lim

7

Probiotics, Prebiotics and Postbiotics on Mitigation of Depression Symptoms: Modulation of the Brain–Gut–Microbiome Axis

Biomolecules 11(7) (2021)

Agata Chudzik; Anna Orzyłowska; Radosław Rola; Greg J. Stanisz

8

The Gut Microbiome in Depression and Potential Benefit of Prebiotics, Probiotics and Synbiotics: A Systematic Review of Clinical Trials and Observational Studies

International Journal of Molecular Sciences 23(9) (2022)

Sauliha Rabia Alli; Ilona Gorbovskaya; Jonathan C.W. Liu; Nathan J. Kolla; Lisa C. Brown; Daniel J. Müller

9

Gut Microbiota in Anxiety and Depression: Unveiling the Relationships and Management Options

Pharmaceuticals 16(4) (2023)

Akash Kumar; Jhilam Pramanik; Nandani Goyal; Dimple Chauhan; Bhagavathi Sundaram Sivamaruthi; Bhupendra Gopalbhai Prajapati; Chaiyavat Chaiyasut

10

PROVIT: Supplementary Probiotic Treatment and Vitamin B7 in Depression—A Randomized Controlled Trial

Nutrients 12(11) (2020)

Eva Z. Reininghaus; Martina Platzer; Alexandra Kohlhammer-Dohr; Carlo Hamm; Sabrina Mörkl; Susanne Bengesser; Frederike T. Fellendorf; Theressa Lahousen-Luxenberger; Birgitta Leitner-Afschar; Helmut Schöggl; Daniela Amberger-Otti; Walter Wurm; Robert Queissner; Armin Birner; Valerie S. Falzberger; Annamaria Painold; Werner Fitz; Martina Brunnmayr; Alexandra Rieger; Jolana Wagner‐Skacel; Alexander Maget; Renate Unterweger; Karin Schwalsberger; Bernd Reininghaus; Melanie Lenger; Thomaz F. S. Bastiaanssen; Nina Dalkner

11

Psychobiotics: The Next-Generation Probiotics for the Brain

Current Microbiology 78(2) (2021)

Richa Sharma; Deesha Gupta; Rekha Mehrotra; Payal Mago

12

Gut-Brain Axis: Role of Microbiome, Metabolomics, Hormones, and Stress in Mental Health Disorders

Cells 13(17) (2024)

Ankita Verma; Sabra S. Inslicht; Aditi Bhargava

13

Effect of probiotics on depressive symptoms: A meta-analysis of human studies

Psychiatry Research 282 (2019)

Kah Kheng Goh; Yen-Wenn Liu; Po‐Hsiu Kuo; Yu-Chu Ella Chung; Mong‐Liang Lu; Chun-Hsin Chen

15

Updated Review and Meta-Analysis of Probiotics for the Treatment of Clinical Depression: Adjunctive vs. Stand-Alone Treatment

Journal of Clinical Medicine 10(4) (2021)

Viktoriya L. Nikolova; Anthony James Cleare; Allan Hunter Young; James M. Stone

16

The effects of co-administration of probiotics and prebiotics on chronic inflammation, and depression symptoms in patients with coronary artery diseases: a randomized clinical trial

Nutritional Neuroscience 25(8) (2021)

Jalal Moludi; Hamed Khedmatgozar; Seyed Mostafa Nachvak; Hadi Abdollahzad; Mehdi Moradinazar; Ali Sadeghpour Tabaei

17

The effects of probiotic supplementation on mental health, biomarkers of inflammation and oxidative stress in patients with psychiatric disorders: A systematic review and meta-analysis of randomized controlled trials

Complementary Therapies in Medicine 49 (2020)

Elaheh Amirani; Alireza Milajerdi; Hamed Mirzaei; Hamidreza Jamilian; Mohammad Alì Mansournia; Jamal Hallajzadeh; Amir Ghaderi

18

Effect of prebiotics, probiotics, synbiotics on depression: results from a meta-analysis

BMC Psychiatry 23(1) (2023)

Qin Zhang; Bing Chen; Jinghui Zhang; Jingyi Dong; Jianglin Ma; Yuyan Zhang; Kangyu Jin; Jing Lü

19

The role of prebiotics in cognition, anxiety, and depression

European Neuropsychopharmacology 34 (2020)

Igor Henrique Rodrigues de Paiva; Eduardo Pereira Duarte-Silva; Christina Alves Peixoto

20

Can psychobiotics “mood” ify gut? An update systematic review of randomized controlled trials in healthy and clinical subjects, on anti-depressant effects of probiotics, prebiotics, and synbiotics

Clinical Nutrition 39(5) (2019)

Elnaz Vaghef‐Mehrabany; Vahid Maleki; Maryam Behrooz; Fatemeh Ranjbar; Mehrangiz Ebrahimi‐Mameghani

21

Mind, Mood and Microbiota—Gut–Brain Axis in Psychiatric Disorders

International Journal of Molecular Sciences 25(6) (2024)

Corneliu Toader; Nicolaie Dobrin; Daniel Costea; Luca-Andrei Glavan; Răzvan-Adrian Covache-Busuioc; David-Ioan Dumitrascu; Bogdan-Gabriel Bratu; Horia Petre Costin; Alexandru Vlad Ciurea

22

Probiotic, prebiotic, synbiotic and fermented food supplementation in psychiatric disorders: A systematic review of clinical trials

Neuroscience & Biobehavioral Reviews 158 (2024)

Carlos Ribera; Joan Vicent Sánchez‐Ortí; Gerard A. Clarke; Wolfgang Marx; Sabrina Mörkl; Vicent Balanzá‐Martínez

24

The effects of psychobiotics on the microbiota-gut-brain axis in early-life stress and neuropsychiatric disorders

Progress in Neuro-Psychopharmacology and Biological Psychiatry 105 (2020)

Annie Tremblay; Lucie Lingrand; Morgane Maillard; Berengere Feuz; Thomas A. Tompkins

25

Clinical and psychological responses to synbiotic supplementation in obese or overweight adults: A randomized clinical trial

Complementary Therapies in Medicine 47 (2019)

Amir Hadi; Mojtaba Sepandi; Wolfgang Marx; Sajjad Moradi; Karim Parastouei

26

Effectiveness of Psychobiotics in the Treatment of Psychiatric and Cognitive Disorders: A Systematic Review of Randomized Clinical Trials

Nutrients 16(9) (2024)

Freiser Eceomo Cruz Mosquera; Santiago Lizcano Martinez; Yamil Liscano

27

Nutrition-based interventions for mood disorders

Expert Review of Neurotherapeutics 21(3) (2021)

Laís Bhering Martins; Jenneffer Rayane Braga Tibães; Marsal Sanches; Felice N. Jacka; Michael Berk; Antônio Lúcio Teixeira

28

Food & mood: a review of supplementary prebiotic and probiotic interventions in the treatment of anxiety and depression in adults

BMJ Nutrition Prevention & Health 3(2) (2020)

Sanjay Noonan; Meena Zaveri; Elaine Macaninch; Kathy Martyn

29

Neuroinflammation, Microbiota-Gut-Brain Axis, and Depression: The Vicious Circle

Journal of Integrative Neuroscience 22(3) (2023)

Sandy Reyes-Martínez; Lorena Segura-Real; Ana Pamela Gómez-García; Emiliano Tesoro-Cruz; Luis Alejandro Constantino-Jonapa; Amedeo Amedei; María Magdalena Aguirre‐García

30

Psychobiotics as treatment for anxiety, depression, and related symptoms: a systematic review

Nutritional Neuroscience 24(12) (2019)

Kristen S. Smith; Michael W. Greene; Jeganathan Ramesh Babu; Andrew D. Frugé

31

The Role of Probiotics and Their Metabolites in the Treatment of Depression

Molecules 28(7) (2023)

Monika Elżbieta Jach; Anna Serefko; Aleksandra Szopa; Ewa Sajnaga; Hieronim Golczyk; Leandro Soares Santos; Kinga K. Borowicz; Elwira Sieniawska

33

Major Depressive Disorder and gut microbiota – Association not causation. A scoping review

Progress in Neuro-Psychopharmacology and Biological Psychiatry 106 (2020)

Igor Łoniewski; Agata Misera; Karolina Skonieczna‐Żydecka; Mariusz Kaczmarczyk; Karolina Kaźmierczak-Siedlecka; Błażej Misiak; Wojciech M. Marlicz; Jerzy Samochowiec

34

A comprehensive overview of the effects of probiotics, prebiotics and synbiotics on the gut-brain axis

Frontiers in Microbiology 16 (2025)

Gizem Kezer; Spiros Paramithiotis; Khaoula Khwaldia; Iskandar Azmy Harahap; Martina Čagalj; Vida Šimat; Slim Smaoui; Walid Elfalleh; Fatih Özoğul; Tuba Esatbeyoglu

35

The effect of interventions targeting gut microbiota on depressive symptoms: a systematic review and meta-analysis

CMAJ Open 9(4) (2021)

Mark Hofmeister; Fiona M Clement; Scott Burton Patten; Joyce Li; Laura E. Dowsett; Brenlea Farkas; Liza Mastikhina; Oluwaseun Egunsola; Ruth Diaz; Noah C.A. Cooke; Valerie H. Taylor

36

Systematic review of probiotics as an adjuvant treatment for psychiatric disorders

Frontiers in Behavioral Neuroscience 17 (2023)

Evan Forth; Benjamin J Buehner; Ana Storer; Cassandra Sgarbossa; Roumen V. Milev; Arthi Chinna Meyyappan

37

The Benefits of Prebiotics and Probiotics on Mental Health

Cureus 15(8) (2023)

Karlyle Genevieve Bistas; Jean Paul Tabet

38

Human Gut Microbiota for Diagnosis and Treatment of Depression

International Journal of Molecular Sciences 25(11) (2024)

Olga V. Averina; Elena U. Poluektova; Yana Zorkina; Alexey S. Kovtun; В. Н. Даниленко

39

The Effect of Prebiotics and Probiotics on Levels of Depression, Anxiety, and Cognitive Function: A Meta‐Analysis of Randomized Clinical Trials

Brain and Behavior 15(3) (2025)

Atefeh Zandifar; Rahim Badrfam; Mahdi Mohammaditabar; Bita Kargar; Saba Goodarzi; Amirhossein Hajialigol; Shera Ketabforoush; Afshin Heidari; Hanie Fathi; Arman Shafiee; Hadi Pourjafar

41

The impact of probiotics, prebiotics, and synbiotics on depression and anxiety symptoms of patients with depression: A systematic review and meta-analysis

Journal of Psychiatric Research 188 (2025)

Reza Moshfeghinia; Hossein Nemati; Asal Ebrahimi; Dorsa Shekouh; Saeed Karami; Mohammad Mirahmadi Eraghi; Hoorad Mohagheghzadeh; Jennifer Hunter; Mehdi Pasalar

42

Gut Biome and Mental Health: Do Probiotics Work?

Cureus 15(6) (2023)

Jayakrishna S Madabushi; Priyal Khurana; Nihit Gupta; Mayank Gupta

43

Efficacy and safety of gut microbiome-targeted treatment in patients with depression: a systematic review and meta-analysis

BMC Psychiatry 25(1) (2025)

Bo Pan; Yiming Pan; Yusong Huang; Meng Yi; Yuwei Hu; Xiaoyu Lian; Huizhong Shi; Ming‐Wei Wang; Guifen Xiang; Wen‐Yi Yang; zhong hai liu; Fangfang Xia

44

The Pediatric Microbiota–Gut–Brain Axis: Implications for Neuropsychiatric Development and Intervention

Children 12(11) (2025)

Giuseppe Marano; Greta Sfratta; Ester Maria Marzo; Giorgia Cozzo; Francesca Abate; Gianandrea Traversi; Osvaldo Mazza; Esmeralda Capristo; Eleonora Gaetani; Marianna Mazza

46

The role of probiotics in modulation of the gut-brain axis: a prospective therapy for depression and mood disorders

Frontiers in Pharmacology 16 (2026)

Hao Wang; Yining Chen; Allen Zhao; Zhongxia Shen; Yu Zhang

47

Gut Microbiota and Pathophysiology of Depressive Disorder

Annals of Nutrition and Metabolism 77(Suppl. 2) (2021)

Hiroshi Kunugi

49

The Putative Antidepressant Mechanisms of Probiotic Bacteria: Relevant Genes and Proteins

Nutrients 13(5) (2021)

Elena Poluektova; Roman А. Yunes; В. Н. Даниленко

50

Add‐on probiotics in patients with persistent allergic rhinitis: A randomized crossover clinical trial

The Laryngoscope 129(8) (2019)

Mir Mohammad Jalali‌; Robabeh Soleimani; Ali Alavi Foumani; Hooman Ganjeh Khosravi

51

Effects of synbiotics supplementation on anthropometric and lipid profile parameters: Finding from an umbrella meta-analysis

Frontiers in Nutrition 10 (2023)

Vali Musazadeh; Maryam Mohammadi Anilou; Mahdi Vajdi; Arash Karimi; Sana Sedgh Ahrabi; Parvin Dehghan

52

Gut microbiota in mental health and depression: role of pre/pro/synbiotics in their modulation

Food & Function 12(10) (2021)

Hasnain N. Methiwala; Bhupesh Vaidya; Vamsi Krishna Addanki; Mahendra Bishnoi; Shyam Sunder Sharma; Kanthi Kiran Kondepudi

53

Effects of 4G-beta-D-Galactosylsucrose in patients with depression: A randomized, double-blinded, placebo-controlled, parallel-group comparative study

Journal of Psychiatric Research 148 (2022)

Seiichiro Tarutani; Maiko Omori; Yumiko Ido; Megumu Yano; Tatsushi Komatsu; Takehiko Okamura

54

Effect of Psychobiotics on Psychometric Tests and Inflammatory Markers in Major Depressive Disorder: Meta-Analysis of Randomized Controlled Trials with Meta-Regression

Pharmaceuticals 14(10) (2021)

Agata Misera; Paweł Liśkiewicz; Igor Łoniewski; Karolina Skonieczna‐Żydecka; Jerzy Samochowiec

55

Psychobiotic Therapy: Method to Reinforce the Immune System

Clinical Psychopharmacology and Neuroscience 20(1) (2022)

Karina Teixeira Magalhães‐Guedes

56

Depression-associated gut microbes, metabolites and clinical trials

Frontiers in Microbiology 15 (2024)

Meiling Wang; Zhaoqi Song; Shirong Lai; Furong Tang; Lijun Dou; Fenglong Yang

57

A Reciprocal Link Between Gut Microbiota, Inflammation and Depression: A Place for Probiotics?

Frontiers in Neuroscience 16 (2022)

Ahmed Eltokhi; Iris E. Sommer

58

Effect of gut microbiome on serotonin metabolism: a personalized treatment approach

Naunyn-Schmiedeberg s Archives of Pharmacology 397(5) (2023)

Kristal Potter; Erysa J. Gayle; Subrata Deb

59

The Effects of Synbiotics Administration on Stress-Related Parameters in Thai Subjects—A Preliminary Study

Foods 11(5) (2022)

Ekasit Lalitsuradej; Sasithorn Sirilun; Phakkharawat Sittiprapaporn; Bhagavathi Sundaram Sivamaruthi; Komsak Pintha; Payungsak Tantipaiboonwong; Suchanat Khongtan; Pranom Fukngoen; Sartjin Peerajan; Chaiyavat Chaiyasut

60

The Therapeutic Role of Exercise and Probiotics in Stressful Brain Conditions

International Journal of Molecular Sciences 23(7) (2022)

Ismael Martínez‐Guardado; Silvia Arboleya; Francisco Javier Grijota Pérez; Aleksandra Kaliszewska; Miguel Gueimonde; Natalia Arias

61

PRO-DEMET Randomized Controlled Trial on Probiotics in Depression—Pilot Study Results

Nutrients 15(6) (2023)

Oliwia Gawlik-Kotelnicka; Aleksandra Margulska; Anna Skowrońska; Dominik Strzelecki

63

Probiotics in the Management of Mental and Gastrointestinal Post-COVID Symptomes

Journal of Clinical Medicine 11(17) (2022)

Igor Łoniewski; Karolina Skonieczna‐Żydecka; Joanna Sołek-Pastuszka; Wojciech M. Marlicz

65

When the microbiome helps the brain‐current evidence

CNS Neuroscience & Therapeutics 29(S1) (2023)

Jovana Drljača; Natasa P. Milosevic; Maja Milanović; Ludovico Abenavoli; Nataša Milić

66

Therapeutic modulation of the kynurenine pathway in severe mental illness and comorbidities: A potential role for serotonergic psychedelics

Progress in Neuro-Psychopharmacology and Biological Psychiatry 134 (2024)

Antonella Campanale; Antonio Inserra; Stefano Comai

67

Nutrition and brain health: Implications of Mediterranean diet elements for psychiatric disorders

Schizophrenia Research 281 (2025)

Christa A Akerele; Lauren R Koralnik; Ezequiel Lafont; Caitlin Gilman; Julie Walsh‐Messinger; Dolores Malaspina

68

Microbiota-Gut-Brain Axis and Antidepressant Treatment

Current topics in behavioral neurosciences 66 (2023)

David Antoine Lachmansingh; Aonghus Lavelle; John F. Cryan; Gerard A. Clarke

69

The involvement of the microbiota-gut-brain axis in the pathophysiology of mood disorders and therapeutic implications

Expert Review of Neurotherapeutics 25(1) (2024)

Izabela Guimarães Barbosa; Aline Silva de Miranda; Michael Berk; Antônio Lúcio Teixeira

70

The Therapeutic Impact of Plant-Based and Nutritional Supplements on Anxiety, Depressive Symptoms and Sleep Quality among Adults and Elderly: A Systematic Review of the Literature

International Journal of Environmental Research and Public Health 20(6) (2023)

Darshan Kamat; Yazan A. Al‐Ajlouni; Ryan C.W. Hall

71

Gut microbiota in anxiety and depression: Pathogenesis and therapeutics

Frontiers in Gastroenterology 1 (2022)

Stefano Bibbò; Salvatore Fusco; Gianluca Ianiro; Carlo Romano Settanni; Daniele Ferrarese; Claudio Grassi; Giovanni Cammarota; Antonio Gasbarrini

72

Nutritional Strategies in Major Depression Disorder: From Ketogenic Diet to Modulation of the Microbiota-Gut-Brain Axis

Molecular Neurobiology 62(3) (2024)

Ali Nikdasti; Elaheh Sadat Khodadadi; Felora Ferdosi; Ehsan Dadgostar; Sheida Yahyazadeh; Parasta Heidari; Sajad Ehtiati; Omid Vakili; Seyyed Hossein Khatami

73

Rewiring Mood: Precision Psychobiotics as Adjunct or Stand-Alone Therapy in Depression Using Insights from 19 Randomized Controlled Trials in Adults

Nutrients 17(12) (2025)

Alexandra-Eleftheria Menni; Helen Theodorou; Georgios Tzikos; Ioannis M. Theodorou; Eleni Semertzidou; Veroniki Stelmach; Anne D. Shrewsbury; George Stavrou; Katerina E. Kotzampassi

74

The effect of probiotic supplementation on sleep, depression-like behaviour, and central glucose and lactate metabolism in male and female pubertal mice exposed to chronic sleep disruption

Psychoneuroendocrinology 168 (2024)

Michael Murack; Anthony K. Kadamani; Alexi Guindon-Riopel; Olivia H. Traynor; Umar Iqbal; Stéphane Bronner; Claude Messier; Nafissa Ismail

75

Potential clinical benefits of probiotics, prebiotics, synbiotics, and postbiotics for depression via the microbiota-gut-brain axis

World Journal of Psychiatry 15(5) (2025)

Ling-Yi Dai; Ru-Ru Chen; Hao-Ran Chen; Jia-Hui Yin; Zhenxing Huang; Bo-Wen Yin; Xing-Yan Liu

76

Effects of Probiotics as Adjunctive Therapy to Fluoxetine on Depression Severity and Serum Brain‐Derived Neurotrophic Factor, Cortisol, and Adrenocorticotropic Hormone in Patients With Major Depressive Disorder: A Randomized, Double‐Blind, Placebo‐Controlled Trial

Food Science & Nutrition 13(4) (2025)

Vajihe Elahinejad; Atie Sadat Khorasanian; Mehdi Tehrani‐Doost; Kianoush Khosravi‐Darani; Zahra Mirsepassi; Mohammad Effatpanah; Reza Askari‐Rabori; Shirin Tajadod; Shima Jazayeri

77

Plateau Environment, Gut Microbiota, and Depression: A Possible Concealed Connection?

Current Issues in Molecular Biology 47(7) (2025)

Yajun Qiao; Ruiying Cheng; Xiaohui Li; Huimin Zheng; Juan Guo; Lixin Wei; Tingting Gao; Hongtao Bi

78

Gut microbiota and the tryptophan-kynurenine pathway in anxiety: new insights and treatment strategies

Journal of Neural Transmission 132(7) (2025)

Garry Hunjan; Shiv Shankar Shah; Sourabh Kosey; Khadga Raj Aran

79

The Role of Probiotics and Their Postbiotic Metabolites in Post-COVID-19 Syndrome

Molecules 30(20) (2025)

Monika Elżbieta Jach; Ewa Sajnaga; Marharyta Bumbul; Anna Serefko; Kinga K. Borowicz; Hieronim Golczyk; Marek Kieliszek; Adrian Wiater

80

Understanding the research landscape of over-the-counter herbal products, dietary supplements, and medications evaluated for depressive symptoms in adults: a scoping review

Frontiers in Pharmacology 16 (2025)

Rachael Frost; Aiman Zamri; Silvy Mathew; Adriana Salame; Cini Bhanu; Sukvinder Kaur Bhamra; Juan Carlos Bazo‐Alvarez; Michael Heinrich; Kate R Walters

81

Probiotics as a Treatment for “Metabolic Depression”? A Rationale for Future Studies

Pharmaceuticals 14(4) (2021)

Oliwia Gawlik-Kotelnicka; Dominik Strzelecki

82

The role of the gut microbiota in the pathophysiology of mental and neurological disorders

Psychiatric Genetics 30(4) (2020)

Matteo M. Pusceddu; Josep M Del Bas-Prior

83

Wait-there’s evidence for that? Integrative medicine treatments for major depressive disorder

The International Journal of Psychiatry in Medicine 56(5) (2021)

Stephen J. Warnick; Laraib Mehdi; Jennifer A. Kowalkowski

85

The Gut Connection: A Narrative Review on the In-depth Analysis of Gut Microbiota and Metabolites in Depression

Current Clinical Pharmacology 21(1) (2025)

Ayesha Sultana; Md Sadique Hussain; Mudasir Maqbool; Mohit Agrawal; Ajay Singh Bisht; Navneet Khurana; Gurvinder Singh; Rajesh Kumar

86

Microbial therapeutic tools for human brain disorders: A current overview

Brain Disorders 19 (2025)

Alejandro Borrego-Ruiz; Juan José Borrego

87

The Brain-Gut-Microbiome Axis Across the Life Continuum and the Role of Microbes in Maintaining the Balance of Health

Journal of Integrative Neuroscience 24(8) (2025)

Tyler Halverson; Kannayiram Alagiakrishnan

88

Psychobiotics for the treatment of neuropsychiatric, neurodegenerative, and neurodevelopmental disorders: A systematic review

Progress in Neuro-Psychopharmacology and Biological Psychiatry 145 (2026)

Buddolla Anantha Lakshmi; Viswanath Buddolla; Kumar Shiva Gubbiyappa; Maduru Suneetha; Young Joon Kim

89

Analysis methods for the gut microbiome in neuropsychiatric and neurodegenerative disorders

Computational and Structural Biotechnology Journal 20 (2022)

Jae Gwang Song; Myeong‐Sang Yu; Bomi Lee; Jingyu Lee; Su-Hee Hwang; Dokyun Na; Hyung Wook Kim

90

The Gut Microbiota and Major Depressive Disorder: Current Understanding and Novel Therapeutic Strategies

Current Pharmaceutical Biotechnology 25(16) (2024)

Mohaddeseh Bahmani; Saba Mehrtabar; Ali Jafarizadeh; Sevda Zoghi; Fatemah Sadeghpour Heravi; Amin Abbasi; Sarvin Sanaie; Sama Rahnemayan; Hamed Ebrahimzadeh Leylabadlo

91

Psychobiotics: a new way in psychopharmacology, or How do bacteria manage our brain?

Clinical Microbiology and Antimicrobial Chemotherapy 24(2) (2022)

Irina V. Andreeva; A.V. Tolpygo; V.А. Andreev; Ilya Sulejmanovich Azyzov; Golman I.A.; N. N. Osipova; V. V. Privolnev; Оlga U. Stetsiouk; V. V. Sokolovskaya

92

Could psychobiotics and fermented foods improve mood in middle-aged and older women?

Maturitas 181 (2023)

Souzan J. Zidan; Serene Hilary; Ayesha Salem Al Dhaheri; Leila Cheikh Ismail; Habiba I. Ali; Vasso Apostolopoulos; Lily Stojanovska

93

The Canadian Network for Mood and Anxiety Treatments Task Force Recommendations for the Use of Probiotics, Prebiotics, Synbiotics, and Fecal Microbiota Transplants in Adults With Major Depressive Disorder: Recommandations du Groupe de travail du Réseau canadien pour le traitement des troubles de l’humeur et de l’anxiété (Canadian Network for Mood and Anxiety Treatments, CANMAT) concernant l’utilisation des probiotiques, des prébiotiques, des symbiotiques et de la transplantation de microbiote fécal chez les adultes atteints de trouble dépressif majeur

The Canadian Journal of Psychiatry 71(5) (2025)

Anees Bahji; Elisa Macedo Brietzke; Noah C.A. Cooke; Fiona M Clement; Benicio Noronha Frey; Mark Hofmeister; Sidney H. Kennedy; Raymond Wing Moon Lam; Roumen V. Milev; Dina Moinul; Sagar V. Parikh; Scott Burton Patten; Arun V Ravindran; Joshua Daniel Rosenblat; Zainab Samaan; Ayal Schaffer; April Saleem; Serge Beaulieu; Valérie Tourjman; Michael Van Ameringen; Simone Natalie Vigod; Lakshmi N. Yatham; Valerie H. Taylor; Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce

94

Probiotics: current regulatory aspects of probiotics for use in different disease conditions

Elsevier eBooks (2021)

Maja Šikić Pogačar; Dušanka Mičetić‐Turk; Sabina Fijan

96

Psychobiotics and Dietary Supplementation in the Clinical Practice: A Mini Review

Journal of Biomedical Research & Environmental Sciences 3(9) (2022)

Joanna Michalina Jurek; Marcin Owczarek

97

The interplay between gut microbiome, epigenetics, and substance use disorders: from molecular to clinical perspectives

European Journal of Pharmacology 998 (2025)

Keivan Sahebi; Mona Arianejad; Soha Azadi; Fatemeh Hosseinpour-Soleimani; Radmehr Kazemi; Amir Tajbakhsh; Manica Negahdaripour

98

The Impact of Gut Microbiota on Mental Health

Nutritional neurosciences (2024)

Mahmoud Tarek Hefnawy; Kholoud Elsamman; Abdallah Abbas; Yousef Hawas

99

Efficacy of Adjunct PRObiotics as Compared to the Standard Care in Moderate Unipolar Depression Among Geriatric Patients: A Randomized Double‐Blind Placebo‐Controlled Pilot Multi‐Center Trial ( PRODG )

Journal of the American Geriatrics Society 74(7) (2026)

Preeti Sinha; Prasun Chatterjee; Preethy Kathiresan; Karishma Sundara Raju; Rasika Panwar; Aparna Mukherjee; Gunjan Kumar; Jerin Jose Cherian; Anoop Velayuthan; Avinash Chakrawarty; Sarnendu Mondal; Manoj Kalita; Spriha Kamboj; Sreyashi Sen; Mounamukhar Bhattacharjee; Manaswini Mondal; Kalyan Bhowmik; Sovonlal Mukherjee; Indranil Saha; Atanu Kumar Dutta; Asim Saha; Amit Chakrabarti; Abhinaba Ghosh; Saibal Das

100

Gut microbiome as a therapeutic target in the treatment of depression and anxiety

S S Korsakov Journal of Neurology and Psychiatry 121(11) (2021)

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101

Probiotics Lactobacillus Plantarum PS128 intervention in two patients with major depressive disorder

Taiwanese Journal of Psychiatry 33(2) (2019)

Chien-Chih Pan; Chun-Hsin Chen; Jr-Shian Chang; Yi-Hang Chiu

102

The effect of probiotics on depressive symptoms: A meta-analysis of randomized controlled trails

Research Society and Development 10(9) (2021)

Vitor Palmares Oliveira e Silva; Marcelo Palmares Oliveira e Silva; Carlos Roberto Weber Sobrinho; Rodrigo C. Marques; Flávio Cardoso de Souza Júnior; Marcilio Lins Aroucha

103

Psychobiotics

Oxford University Press eBooks (2020)

Sabrina Mörkl; Mary Butler; Franziska Cichini; John F. Cryan; Timothy G. Dinan

105

A RELAÇÃO ENTRE DISBIOSE INTESTINAL E DEPRESSÃO: UM OLHAR SOBRE O EIXO INTESTINO-CÉREBRO

Revista Tópicos. 16(2) (2024)

Ítalo Carneiro de Oliveira; João Felippe Donaire Rapozero; Amanda Souza Moreira; Nelson Pinto Gomes; Ártemis Sandra Borges Nunes Costa; Ana Rita Barreiro Chaves; Francisco Leonardo de Araújo Sampaio; Matheus Gouveia Lourenço; Luane Magalhães Pinheiro; Jhonny Richard de Souza

106

The role of microbiome in gut-brain-axis dysbiosis causing depression: From mechanisms to treatment

International review of neurobiology 180 (2025)

Junqiao Mi; Julia Morys; Marta Maria Nowacka-Chmielewska; Małgorzata Burek

107

Gut microbiome-based solutions for lifestyle-related disorders

Elsevier eBooks (2025)

Eva Maria Medina-Rodriguez; Marta Olivares; Marina Romaní‐Pérez; Yolanda Sanz

109

Nutraceuticals and phytoceuticals for the treatment of major depressive disorder: a systematic review and network meta-analysis

Molecular Psychiatry 31(12) (2026)

Michele Fornaro; Chiara Di Lorenzo; Nicolás A. Núñez; Alessandro Miola; Raffaella Calati; Andre Ferrer Carvalho; Luca Steardo; Brendon Stubbs; David Mischoulon; Christoph Ulrich Correll; Marco Solmi

110

Psychobiotics in the treatment of depression: a new look at mental health – a systematic search review

Revista Científica Multidisciplinar Núcleo do Conhecimento (2022)

Taiane Coelho; Raquel Kerpel

112

Probiotic Bacteria in the Correction of Depression Symptoms, Their Active Genes and Proteins

Russian Journal of Genetics 57(9) (2021)

Elena U. Poluektova; В. Н. Даниленко

113

Recent Advances and Future Trends in Fermented and Functional Foods

MDPI eBooks (2022)

Jayanta Kumar Patra; Han‐Seung Shin; Spiros Paramithiotis

114

Psicobiotici nel trattamento della depressione: un nuovo sguardo sulla salute mentale – una revisione sistematica della ricerca

Revista Científica Multidisciplinar Núcleo do Conhecimento (2022)

Taiane Coelho; Raquel Kerpel

115

Psychobiotiques dans le traitement de la dépression : un nouveau regard sur la santé mentale – une revue de recherche systématique

Revista Científica Multidisciplinar Núcleo do Conhecimento (2022)

Taiane Coelho; Raquel Kerpel

116

Psicobióticos en el tratamiento de la depresión: una nueva mirada a la salud mental: una revisión de búsqueda sistemática

Revista Científica Multidisciplinar Núcleo do Conhecimento (2022)

Taiane Coelho; Raquel Kerpel

118

Psicobióticos no tratamento da depressão: um novo olhar para a saúde mental – revisão de busca sistematizada

Revista Científica Multidisciplinar Núcleo do Conhecimento (2022)

Taiane Coelho; Raquel Kerpel

119

Psychobiotika in der Behandlung von Depressionen: ein neuer Blick auf die psychische Gesundheit – eine systematische Überprüfung der Suche

Revista Científica Multidisciplinar Núcleo do Conhecimento (2022)

Taiane Coelho; Raquel Kerpel

120

気分障害におけるサプリメント

Kyushu Neuropsychiatry 69(2) (2024)

岳 寺尾

121

Synbiotic Supplementation Lowers Posttraumatic Stress Disorder Biomarkers in Women Who Experienced Domestic Violence

Violence and Gender 12(1) (2025)

Amir Mirzaie Hajibekandeh; Seyedeh Mohadeseh Badri; Seyedeh Maryam Mousavi; Houra Pourghaffar Maghferati; Farzam Ajamian

123

Designing Nutritional Interventions for Mental Health

Nutritional neurosciences (2025)

Nada Ibrahim Hendi; Moaz Elsayed Abouelmagd; Aya Mohammed Sharkawy; Esraa M. Jasim; Ahmed Mostafa Amin

124

Therapeutic Role of Probiotics in Regulating Mental Health: Gut-Brain Cross-Talk

Journal of Environmental Pathology Toxicology and Oncology 45(3) (2025)

Kanchanlata Tungare; Nilofar Khan; Pallavi Gurav; Velis Sonani; Vinothkannan Ravichandran; Pamela Jha; Renitta Jobby

125

Gut microbiota‐targeted interventions for depression in adolescents and young adults: Mechanisms, evidence strength and clinical strategies—A narrative review

General Psychiatry 39(4) (2026)

Hanchen Hou; Yinan Li; Wanting Tang; Yiwen Gao; Yuanyuan Tian; Fei Chen; Lige Zhang; Jushuang Zhang; Xiaoxia Xu; Yao Li; Yi Li; Qingshan Wang; Lingli Liu; Teng Teng; Hao Wu; Xinyu Zhou

126

Anxiolytic and antidepressant potential of psychobiotics

Kazan medical journal 107(4) (2026)

Yu. A. Sergeev; Eduard Beyer; Igor Alexandrovich Bazikov

128

Short-chain fatty acids as key mediators of the microbiota–gut–brain axis in chronic cerebral hypoperfusion: mechanisms and therapeutics

Molecular Medicine 32(1) (2026)

Junchen Si; Peijian Wang; Zhongchen Li; Jiheng Hao; Jiyue Wang; Liyong Zhang

129

The Psychobiotics in Depression and Anxiety: Efficacy, Mechanisms, and the Underestimated Risk of Antibiotic Resistance

Journal of Education Health and Sport 95 (2026)

Alicja Solecka; Alicja Nierychlewska; Marcin Falis; Robert Bronisławski; Agata Bronisławska; Damian Stencelewski; Laura Magdalena Sikorska; Magdalena Aleksandra Boniecka; Michalina Grudzińska; Kamila Roman

130

Gut Microbiota Modulation in CNS Disorders: Therapeutic Strategies and Implications for Drug Efficacy

Molecular Neurobiology 63(1) (2026)

Lamiaa A. Ahmed; Khaled F. Al‐Massri