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Background:
TNF-? is one of the most potent cytokines in proinflammatory reactions.
Archives of Pediatric Infectious Diseases
The Official Journal of Pediatric Infections Research Center, SBMU
Urinary Tumor Necrosis Factor-Alpha a Good Indicator for Inflammatory Response in Pyelonephritis
Author(s):
Masoumeh Mohkam1,*, Sedigheh Rafiei Tabatabaei1, Fahimeh Asgarian1, Shahnaz Armin1, Alireza Fahimzad1, Mostafa Sharifian1, Reza Dalirani11Pediatric Infections Research Center, Shahid Beheshti University of Medical sciences, [email protected], IR Iran
Published online:Jul 15, 2013
Article type:Research Article
Received:Nov 21, 2012
Accepted:Jan 01, 2013
How to Cite:Mohkam M, Rafiei Tabatabaei S, Asgarian F, Armin S, Fahimzad A, et al. Urinary Tumor Necrosis Factor-Alpha a Good Indicator for Inflammatory Response in Pyelonephritis. Arch Pediatr Infect Dis. 2013;1(2):. doi: https://doi.org/10.5812/pedinfect.9114
Abstract
Objectives:
This article contributes to evaluate the correlation between urinary TNF-? and inflammatory response markers in children with acute pyelonephritis.
Patients and Methods:
This cross sectional study, was performed on children with acute pyelonephritis. Fresh random urine samples were obtained before treatment of pyelonephritis. Urine samples were tested for TNF-? and creatinine. We also evaluated our patients with routine biochemical studies.
Results:
One hundred and twenty children with acute pyelonephritis were evaluated. Urinary TNF-?/Cr was 0.0051 0.00083 Pg/g creatinine. The authors found out a significant difference in urinary TNF-?/Cr between patients who have normal and abnormal levels of urine leukocytes, urine protein, urine culture, erythrocyte sedimentation rate and C- reactive protein. This study revealed a significant correlation between urinary TNF-alpha and urine WBC (r = 0.36, P value = 0.02), ESR (r = 0.75, P value = 0.03) and CRP (r = 0.58, P value = 0.02).
Conclusions:
We concluded that urinary TNF-?/Cr might be a good indicator for inflammatory response in children with acute pyelonephritis.
Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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