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Archives of Clinical Infectious Diseases

Infectious Diseases and Tropical Medicine Research Center, SBUMS

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Occurrence of Class 2 Integrons Among Multi-Drug Resistant Shigella Sonnei Isolated from Tehran, Iran in 2005

Author(s):
Reza RanjbarReza RanjbarReza Ranjbar ORCID1,*, Shohreh FarshadShohreh Farshad2, Mohammad RahbarMohammad Rahbar3, Zahra SafiriZahra Safiri1, Caterina MamminaCaterina Mammina4, Mohammad ArjomanzadeganMohammad Arjomanzadegan5
1Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
2Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
3Department of Microbiology, Iranian Reference Health Laboratories, Tehran, IR Iran
4Dipartimento di Scienze per la Promozione della Salute G. DAlessandro, Universit di Palermo, Via del Vespro, Palermo, Italy
5Research Center of Infectious Disease, Arak University of Medical Sciences, Arak, IR Iran
Archives of Clinical Infectious Diseases:Vol. 5, issue 3; 156-160
Published online:Jul 31, 2010
Article type:Brief Report
How to Cite:Ranjbar R, Farshad S, Rahbar M, Safiri Z, Mammina C, et al. Occurrence of Class 2 Integrons Among Multi-Drug Resistant Shigella Sonnei Isolated from Tehran, Iran in 2005. Arch Clin Infect Dis. 2010;5(3):. doi:

Abstract

Background:

Shigellosis is one of the major causes of morbidity in children with diarrhea in Iran. Integrons play an important role in the evolution and dissemination of multidrug resistance in gram-negative bacteria. The occurrence of integrons among Shigella spp. is frequently reported throughout the world. The aim of this study was to assess the occurrence of class 2 integrons among the multi drug resistant S. sonnei isolated from Iranian children in 2005.

Materials and methods:

The study was conducted in two major pediatric hospitals in Tehran, Iran. Fecal specimens and rectal swab collected from patients were cultured and identified as Shigella by the conventional methods. Antimicrobial susceptibility test was performed according to the standard CLSI guideline. Multi-drug resistant isolates of S. sonnei were further examined for the presence of class 2 integron by PCR using specific primers. Amplicons were

Results:

A total of 83 multi-drug resistant S. sonnei strains were isolated. Of these, 45 (54%) exhibited a class 2 integron of 2.1 kbp, and 34 (41%) a class 2 integron of 1.3 kbp. Class 2 integrons were not detected in four isolates.

Conclusion:

The results showed an increased occurrence of class 2 integron carrying S. sonnei isolated from children in Tehran in 2005.

Keywords
Shigella Sonnei
Class 2 Integron
Multi-Drug Resistant

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