Archives of Clinical Infectious Diseases
Infectious Diseases and Tropical Medicine Research Center, SBUMS
Authors
Antibiotic prophylaxis would benefit all cesarean section patients and may decrease morbidity and length of hospital stay. The present study was conducted to determine whether the administration of cefazolin prior to skin incision was superior to administration at the time of umbilical cord clamping for prevention of post-cesarean maternalneonatal infections morbidity.
This was a randomized, double-blinded clinical trial. During the study period, 287 cesarean sections for singleton term pregnancies with intact membranes or passed less than 18 hours from rupture of membrane were entered. A total of 196 patients received 2gr cefazolin before incision and 91 patients received 2gr cefazolin after cord clamping. The occurrence of surgical site opening, total infectious morbidity and neonatal complications were
compared between these groups.
Two groups were demographically identical. Rate of IV line need (RR=1.87, 95%CI:0.21-17.02), neonatal sepsis (RR=1.39, 95%CI:0.14-13.64) and NICU admission (RR=0.19, 95%CI: 0.21-17.02) were not significantly differed between groups.
We suggest the standard cefazolin prophylaxis (after cord clamping) for elective cesarean section and cefazolin before incision for non elective cesarean section. Therefore, administration of prophylactic cefazolin prior to incision will not increase the rate of neonatal sepsis.
© 2009, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Movahed F, Soofizadeh N. Comparison of two infection control regimens in cesarean section. J Inflamm Dis. 2024;7(1):e154925. doi:
Mosadegh M, Noori N, Ghasemi M. Comparison of Cesarean Surgical Site Infection in Patients Treated with Cefazolin and Cefazolin-Azithromycin Regimes: A Quasi-experimental Study in a Developing Country. Int J Infect. 2022;9(1):e119790. doi: https://doi.org/10.5812/iji.119790
Borhanzehi S, Yaghoubinia F, Ghasemi M, Pishkar Mofrad Z. The Impact of a Care Bundle on the Prevention of Post-cesarean Surgical Site Infection. Med Surg Nurs J. 2023;12(4):e150616. doi: https://doi.org/10.5812/msnj-150616
Veisi F, Zangeneh M, Malekkhosravi S, Rezavand N, Hemiari K, et al. Subcutaneous vicryl suture covering efficacy on wound complications after cesarean section. J Kermanshah Univ Med Sci. 2011;15(3):e79353. doi:
Rakhshani Moghaddam F, Razavi M, Delaramifar Z. Prevalence and Risk Factors of Surgical Site Infection Following Cesarean Section. J Kermanshah Univ Med Sci. 2025;29(1):e148572. doi: https://doi.org/10.5812/jkums-148572
More by these authors
Last Update: 1 month ago
Last Update: 1 month ago
Last Update: 1 month ago
Last Update: 5 days ago
Last Update: 1 hour ago
Last Update: 2 days ago
