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Objectives:
This study was conducted to assess the prevalence of Hepatitis C virus (HCV), Hepatitis B virus (HBV) and Human immunodeficiency virus (HIV) among hemophilia and thalassemia patients.
Archives of Clinical Infectious Diseases
Infectious Diseases and Tropical Medicine Research Center, SBUMS
e-ISSN 2345-2641
Prevalence of Hepatitis C Virus, Hepatitis B virus, Human Immunodeficiency Virus and Related Risk Factors Among Hemophilia and Thalassemia Patients in Iran
Authors
1Associate Professor, Department of Gastroenterology, Isfahan Liver Disease research center, Isfahan, IR Iran
2Resident, Department of Internal Medicine
3Epidemiologist
4Associate Professor, Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IR Iran.
*Corresponding Author: Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IR Iran, shahshahan@med.mui.ac.ir. Tel: Tel: +98-913 113 2926. Fax: +98 311 222 9877. Email: shahshahan@med.mui.ac.ir
Archives of Clinical Infectious Diseases:Vol. 6, issue 2
Published online:Apr 30, 2011
Article type:Research Article
How to Cite:Kalantari H, Mirzabaghi A, Akbari M, Shahshahan Z. Prevalence of Hepatitis C Virus, Hepatitis B virus, Human Immunodeficiency Virus and Related Risk Factors Among Hemophilia and Thalassemia Patients in Iran. Arch Clin Infect Dis. 2011;6(2):. doi:
Abstract
Patients and Methods:
Present study was conducted from October 2008 to December 2010 in Isfahan, Iran. One thousand one hundred and sixty adult multi-transfused patients (822 males, 338 females, mean age 22.711.5 years) suffering from beta-thalassemia (n = 545) and hemophilia (n=615) were enrolled in the study. Blood samples were obtained from the patients and were tested for HBs Ag, Anti-HCV Ag and Anti- HIV Ab. HCV positive patients underwent genotype determination.
Results:
Of 545 thalassemia patients, 312(57.2%) were male and 233 (42.8%) were female. From 615 hemophilia
patients, 511(83%) were male and 104 (17%) were female. Chronic hepatitis was detected in 505(82.1%) hemophilia patients of which 495 (98%) were HCV Ab positive and 10 (2%) had HBsAg positive. The prevalence of HCV Ab positive and HBsAg positive in 56 (11%) thalassemia patients with chronic hepatitis was 50 (89.2%) and 6 (10.8%) respectively. None of the thalassemia and hemophilia patients were positive for HIV Ab. History of hepatitis in family is the major risk factors and HCV genotype 1 was the major genotype in our patients.
Conclusion:
HCV is the major virus of concern in multi-transfused patients. The strategies for prevention of HCV, HBV and HIV and safety of blood products in this respect have indeed been successful.
Highlights
Copyright
© 2011, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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